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One of the major mechanisms involved in acetaminophen (APAP)induced hepatotoxicity is hepatocyte nuclear factor 4a (HNF4a)mediated activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR). In the present study, we investigated the role of miR-561 and its target gene DAX-1 encoding a corepressor of HNF4a in the process of APAP-induced hepatotoxicity. We used both human ...

cited—that of mothers aged 15–19 with partners aged 20 or older; in their study, 65% of 15–19-year-old mothers had a partner aged 20 or older.5 Males and Chew took a similar conceptual approach, identifying “school-aged” mothers (ages 10–18) and their non–school-aged partners (19 or older).6 Grouping together 15–19-year-olds and their partners ages 20 and older may misrepresent the issue of ado...

Previous studies have revealed an increased fractional anisotropy and greater thickness in the anterior parts of the corpus callosum in meditation practitioners compared with control subjects. Altered callosal features may be associated with an altered inter-hemispheric integration and the degree of brain asymmetry may also be shifted in meditation practitioners. Therefore, we investigated diff...

We review the organization of the neural networks that underlie haptic object processing and compare that organization with the visual system. Haptic object processing is separated into at least two neural pathways, one for geometric properties or shape, and one for material properties, including texture. Like vision, haptic processing pathways are organized into a hierarchy of processing stage...

The study analyses the phonological interference of phoneme pronunciation [q] by Sundanese and Javanese speakers compared with Arabic speakers. researchers used a descriptive comparative qualitative method. listened, took notes, documented voice recordings male students from ethnic groups when reading Qur'an to collect research data analyse it using Praat software version 6.2.13. From results r...