This study was undertaken to determine the roles of individual alpha/beta 1 integrin heterodimers in promoting cellular interactions with the different attachment-promoting domains of laminin (LN). To do this, antibodies to the integrin beta 1 subunit or to specific integrin alpha subunits were tested for effects on cell attachment to LN, to elastase fragments E1-4 and E1, derived from the shor...

Integrins can exist in different functional states with low or high binding capacity for particular ligands. We previously provided evidence that the integrin a 6 b 1, on mouse eggs and on a 6-transfected cells, interacted with the disintegrin domain of the sperm surface protein ADAM 2 (fertilin b ). In the present study we tested the hypothesis that different states of a 6 b 1 interact with fe...

Integrins make a choice ignaling researchers have only a few factors with which to explain a whole lot of biology. On page 407, Goel et al. describe how two integrin variants channel the actions of a single factor, insulin-like growth factor (IGF), into two distinct pathways that induce either adhesion or proliferation. The ␤ 1A integrin variant was known to be associated with proliferation and...

Integrins make a choice ignaling researchers have only a few factors with which to explain a whole lot of biology. On page 407, Goel et al. describe how two integrin variants channel the actions of a single factor, insulin-like growth factor (IGF), into two distinct pathways that induce either adhesion or proliferation. The ␤ 1A integrin variant was known to be associated with proliferation and...

Integrins make a choice ignaling researchers have only a few factors with which to explain a whole lot of biology. On page 407, Goel et al. describe how two integrin variants channel the actions of a single factor, insulin-like growth factor (IGF), into two distinct pathways that induce either adhesion or proliferation. The ␤ 1A integrin variant was known to be associated with proliferation and...

inflammation of blood vessels is a characteristic feature of kawasaki disease. neutrophils play a key role in the inflammatory responses where movement of neutrophils toward the site of inflammation depends on cd11b/cd18 expression as adhesion molecules on these cells. the purpose of this study was to investigate cd11b/cd18 expression in patients with kawasaki disease upon diagnosis and after t...

Integrin A5B1 is overexpressed on endothelial cells of tumor vessels and is uniformly and rapidly accessible to antibodies in the bloodstream. Here, we determined whether antibodies rapidly gain access to integrin overexpressed on the abluminal (basolateral) surface of endothelial cells through vascular leakiness or whether the rapid accessibility results instead because the integrin is overexp...

Integrins link the extracellular matrix to the cellular cytoskeleton and serve important roles in cell growth, differentiation, migration, and survival. Ablation of beta1 integrin in all murine tissues results in peri-implantation embryonic lethality. To investigate the role of beta1 integrin in the myocardium, we used Cre-LoxP technology to inactivate the beta1 integrin gene exclusively in ven...