نتایج جستجو برای: 5ht1a
تعداد نتایج: 161 فیلتر نتایج به سال:
Intracellular recordings were made from neurons of the nucleus prepositus hypoglossi in slices of guinea pig medulla. 5-HT (serotonin) caused a hyperpolarization followed by a late depolarization. The hyperpolarization was mediated by 5-HT1A receptor activation and could be selectively blocked by pindobind-5HT1A (PBD). 5-HT then caused a depolarization only. A selective 5-HT2 agonist, (+)-1-(2,...
UNLABELLED We evaluated the suitability of fluorocarazolol for in vivo studies of cerebral beta-adrenoceptors because (S)-1'-[18F]fluorocarazolol has a higher affinity to beta-adrenoceptors than to serotonergic receptors (pKi beta 1 9.4, beta 2 10.0, 5HT1A 7.4, 5HT1B 8.1) and rapidly crosses the blood-brain barrier. METHODS The (S)-[18F]fluorocarazolol (74 MBq, > 37 TBq/mmol) was intravenousl...
Next-generation antipsychotics- Trends and perspectives beyond dopaminergic and glutamatergic agents
Introduction Three generations of antipsychotics, all which are based on the dopaminergic hypothesis schizophrenia, available for clinical use. Still, more than 66% patients diagnosed with schizophrenia spectrum disorders (SSD) could not achieve remission. Also, glutamatergic is supported by translational models this disease, even if antipsychotics derived from conceptual framework yet market. ...
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Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration. The aim of this study was to determine if a 5-HT(1A) receptor agonist can reduce lipofuscin accumulation, reduce oxidative damage and prevent retinal cell loss both in vitro and in vivo. Autophagy-derived and photoreceptor oute...
Dear Editor, Tourette syndrome (TS) is characterized by chronic motor and vocal tics. In the ‘60s, neuroleptics have started to be used on TS and became the most efficient medications. Most used neuroleptics which have been reported in controlled studies or case reports are haloperidol, pimozide, sulpiride, risperidone, olanzapine and ziprazidone.1 Since then, typical neuroleptics have been dec...
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