Physiologic and anatomic changes following unilateral pubnonary irradiation up to 6,000 rads in dogs were studied. Fractionate irradiation was given to the right lung of 11 dogs divided into three groups which received 2,000, 4,000 and 6,000 rads respectively. Differential bronchospirometry was serially performed at approximately four week intervals for one year. There was no signfficant change...

Background and Aims Mucosal healing [MH] is an important goal for patients with Crohn's disease [CD], yet is incompletely characterised. We investigated whether MH differed by segments across the colon and ileum in patients who received adalimumab maintenance treatment in the EXTEND study. Methods In this double-blind study in adults with moderate to severe ileocolonic CD and mucosal ulcerati...

Chronic hepatitis C patients often fail to respond to interferon-based therapies. This phase III study aimed at confirming the efficacy and safety of glycyrrhizin in interferon + ribavirin-based therapy non-responders. A randomised, double-blind, placebo-controlled, comparison of glycyrrhizin, administered intravenously 5×/or 3×/week, and 5×/week placebo for 12 weeks to 379 patients, was follow...

BACKGROUND Briakinumab is a monoclonal antibody against the p40 molecule shared by interleukin-12 and interleukin-23, which is overexpressed in psoriatic skin lesions. We assessed the efficacy and safety of briakinumab as compared with methotrexate in patients with psoriasis. METHODS In this 52-week trial, we randomly assigned 317 patients with moderate-to-severe psoriasis to briakinumab, at ...

BACKGROUND Whereas many patients respond quickly to treatment with tumour necrosis factor (TNF) inhibitors, some patients may experience significant but delayed responses. OBJECTIVE To evaluate the clinical response between 12 and 24 weeks in subjects with rheumatoid arthritis from the Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes. METHODS Clinical response was ass...

The purpose of this prospective study was to determine the effect of calcium supplementation in the incidence of hypertensive disorders of pregnancy (gestational hypertension and pre-eclampsia) in nulliparous and high risk women. 300 pregnant women in the 24th week of gestation at the beginning of the study were entered into a double-blind randomized trial. 143 of them who had a positive ro...

OBJECTIVES To report on the efficacy and safety of intravitreal aflibercept in patients with macular edema secondary to central retinal vein occlusion (CRVO) in an integrated analysis of COPERNICUS and GALILEO. PATIENTS AND METHODS Patients were randomized to receive intravitreal aflibercept 2 mg every 4 weeks or sham injections until week 24. From week 24 to week 52, all intravitreal afliber...

AIM The purpose of this study was to identify psychosocial determinants for maintaining weight loss. METHODS 42 obese individuals who achieved a 12% weight loss before entering a 52-week weight maintenance program were interviewed qualitatively. Psychosocial factors related to weight loss maintenance were identified in two contrasting groups: weight reducers and weight regainers. Groups were ...

To report the efficacy of 4-weekly add-on mepolizumab 100 mg SC on health-related quality life (HRQoL) in adults with Chronic Rhinosinusitis Nasal Polyps (CRSwNP) . SYNAPSE (NCT03085797), a randomised, double-blind, placebo-controlled, multicentre, 52-week study, enrolled adult patients highly symptomatic CRSwNP and prior surgery, treated intranasal corticosteroids. Co-primary endpoints: change...