Bear bile was used as a traditional medicine or tonic in East Asia, and ursodeoxycholic acid (UDCA) is the most important compound in bear bile. Further, synthetic UDCA is also used in modern medicine and nutrition; therefore, its further functional effects warrant research, in vitro methods could be used for the fundamental research of its anticancer effects. In this study, the apoptotic effec...

background: angiogenesis, which is required for embryonic development and many physiological events, plays crucial role in many pathological conditions such as tumor growth and metastasis. recent studies indicate anticancer and antitumor properties of saffron against human cancers. many processes are affected by electromagnetic field (emf) and its effect on proliferation and gene expression wer...

The combination of Artemisia iwayomogi and Curcuma longa radix is frequently prescribed for liver diseases in TKM. However, the synergic effects of the two herbs on nonalcoholic steatohepatitis (NASH) have not yet been studied. Therefore, we investigated the anti-NASH effects of the water extract of A. iwayomogi (AI), C. longa radix (CL), and combination of the two herbs (ACE). Hepatic steatosi...

BACKGROUND A combination of mifepristone and misoprostol provides an effective method of medical abortion for early pregnancy. A new route of administration of misoprostol, the sublingual route, was investigated in this study. METHODS One hundred women who requested legal termination of pregnancy up to 63 days were given 200 mg of oral mifepristone followed 48 h later by 800 microg (4 x 200 m...

Lead forms the complexes with xylenol orange in the basic solution. An adsorptivedifferential pulse stripping method for the determination of lead is proposed. The procedureinvolves an adsorptive accumulation of lead on a hanging mercury drop electrode (HMDE) inthe presence of xylenol orange, followed by reduction of adsorbed lead by voltammetric scanusing differential pulse modulation. The opt...

A simple, sensitive and specific HPLC method was validated for the simultaneous determination of benzoic acid and sorbic acid in noodles. Sample preparation involved the extraction with methanol and water (60:40, v/v). The separation was achieved on a GerminiC18 modified silica column (50 mm x 4.6 mm i.d., 5 μm particle diameter). The mobile phase consisted of 0.05 M ammonium acetate (pH 4.4) a...

Perseaamericana Mill (Lauraceae) is a local medicinal plant used in Nigerian ethnomedicine as antimalarial. The aqueous decoction of the root part is a potent remedy against bacterial infections. Hence, the need to investigate the phytochemical and biological activities (antimicrobial and antiplasmodial) of the root back of Perseaamericana. Chromatographic and spectroscopic techniques were used...

BACKGROUND indacaterol is a novel, inhaled once-daily ultra-long-acting β(2)-agonist for the treatment of chronic obstructive pulmonary disease (COPD). OBJECTIVES this study compared the onset of action of single doses of indacaterol 150 and 300 μg with salbutamol 200 μg, salmeterol-fluticasone 50/500 μg, and placebo in moderate-to-severe COPD patients. METHODS this was a multicenter, rando...

BACKGROUND Since Misoprostol Vaginal Insert (MVI - Misodel ®) was approved for labor induction in Europe in 2013, to date, no study has been published comparing MVI to Misoprostol vaginal tablets (MVT). The aim of this study, performed as part of a quality improvement project, was to compare the efficacy and safety of 200 μg MVI versus 25 μg MVT for labor induction in nulliparous women. METHO...

Background. Streptomycetes were and remain a source of new antimicrobial compounds various nature. A wave interest in such research is associated with the possibilities applied genomics to reveal hidden biosynthetic potential streptomycetes, therefore discovery practically valuable products. The problem antibiotic resistance pathogens can be solved by creating compositions active substances dif...