A series of acceptor-acceptor (A-A’) alternated copolymers based on dithienodiketopyrrolo pyrrole were synthesized by copolymerizing it with itself and other different electron-poor monomers. The experimental computed optoelectronic properties four DPP-based copolymers, P(DPP-DPP) (with linear branched chains), copolymer diazapentalene P(DPP-DAP) also dioxothienopyrrolebenzodifurandione P(DPP-B...

Multiple choices of the protein active conformations in flexible metalloenzymes complicate study of their catalytic mechanism. We used three different conformations of human dipeptidyl-peptidase III (DPP III) to investigate the influence of the protein environment on ligand binding and the Zn(2+) coordination. MD simulations followed by calculations of binding free energy components accomplishe...

A series of three donor molecules (DPP-B, DPP-N and DPP-P) based on diketopyrrolopyrrole (DPP) sharing the similar backbone D-π-A-π-D have been investigated. In these molecules, substituents such as pyrene, naphthalene benzene act electron donating end groups, DPP central core unit thiophene has used a bridge between acceptor fragments. Theoretical calculations carried out with help density fun...

BACKGROUND Little is known about the sex-specific effects of cigarette smoking on the level and growth of lung function in adolescence, when 71 percent of people in the United States who smoke tried their first cigarette. METHODS We studied the effects of cigarette smoking on the level and rate of growth of pulmonary function in a cohort of 5158 boys and 4902 girls 10 to 18 years of age, exam...

Drosophila Piwi is the founding member of a gonadal clade of Argonaute proteins that serve as silencing effectors for ∼26-32 nt Piwi-interacting RNAs (piRNAs) [1], and piwi mutants exhibit dramatically rudimentary ovaries [2]. It was proposed that somatic Piwi maintains germline stem cells (GSCs) by promoting Dpp signaling, presumably via cap cells that form the somatic niche for GSCs [3-5]. Ho...

Abstract. A survey of the North Celestial Pole region using the RATAN-600 radio telescope at five frequencies in the range 2.3 to 21.7 GHz is described. Sources were chosen from the NVSS catalogue. The flux densities of 171 sources in the Declination range +75◦ to +88◦ are presented; typical flux density errors are 5-10 percent including calibration errors. About 20 percent of the sources have ...

BACKGROUND Concern about an increasing risk of acute pancreatitis associated with incretin-based drugs, including dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 analogs, has emerged recently. OBJECTIVE This nested case-control study examined the association between the use of DPP-4 inhibitors and acute pancreatitis using Taiwan's National Health Insurance Research Datab...

OBJECTIVES We administered aerosolized histamine to 32 subjects with tetraplegia to determine whether there were differences in spirometric and/or lung volume parameters between responders and nonresponders. RESULTS Baseline pulmonary function parameters revealed mild to moderate restrictive dysfunction. We found that 25 subjects (78%) were hyperreactive to histamine (mean provocative concent...

In a previous search for mutants of Salmonella typhimurium that are defective in heme synthesis, one class that is apparently defective in 5-aminolevulinic acid (ALA) uptake (alu) was found. Here, I describe the characterization of these mutations. The mutations all map to a single locus near 77.5 min on the genetic map, which is transcribed counterclockwise. Nutritional tests, genetic and phys...

Objective Several clinical studies have reported the application of dipeptidyl peptidase-4 (DPP-4) inhibitors as treatments for type 1 diabetes mellitus (T1DM). This study aims to review the outcomes of these existing studies and to discuss the therapeutic effects of DPP-4 inhibitors on T1DM. Methods We thoroughly searched the Medline, Embase, PubMed, and Cochrane Library databases and Clinic...