Abstract Background 5-aminosalicylic acid (5-ASA) is widely used as a first-line treatment for ulcerative colitis (UC), but intolerance sometimes occurs. 5-ASA-intolerance was considered risk factor colectomy in UC patients, no reports have examined which suitable to avoid 5-ASA-intolerant patients. This the first report describing strategy UC. The aims of this study were determine optimal ther...

poly-(alkylcyanoacrylate) ester particles have been used for the preparation of different formulations ranging from ophthalmic delivery systems to cancer chemotherapy carriers in clinic. the aim of this study was to prepare and characterize poly-(methyl ethyl cyanoacrylate) (pmeca) particles containing 5-aminosalicylic acid (5-asa). pmeca particles were prepared using the inverse emulsification...

The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...

Poly-(alkylcyanoacrylate) ester particles have been used for the preparation of different formulations ranging from ophthalmic delivery systems to cancer chemotherapy carriers in clinic. The aim of this study was to prepare and characterize poly-(methyl ethyl cyanoacrylate) (PMECA) particles containing 5-aminosalicylic acid (5-ASA). PMECA particles were prepared using the inverse emulsification...