compound of 5-aminolevulinic acid (5-ala) has herbicide behavior in high concentration. while, it acts as growth regulator at low concentrations and causes resistance to various stresses incluing cold and salibity. therefore the exogenous application of 5-aminolevulinic acid was investigated to induce cold stress tolerance in young soybean plants (glycine max l.). the experiment was conducted a...

After obtaining informed consent, the patient was treated with topical 5-aminolevulinic acid photodynamic therapy (ALA-PDT). Twenty percent ALA (A 7793; Sigma, St Louis, Mo) in an oil-in-water emulsion (Yoshida, Tokyo, Japan) was applied to a 5 3 5-cm area of the right cheek for 4 hours with a light-shielded dressing. On Wood lamp examination, the affected lesion showed numerous dots of vivid r...

BACKGROUND AND AIMS Trypanosoma cruzi is the causative agent of Chagas disease or American trypanosomiasis. The parasite manifests a nutritional requirement for heme compounds because of its biosynthesis deficiency. The aim of this study has been to investigate the presence of metabolites and enzymes of porphyrin pathway, as well as ALA formation in epimastigotes of T. cruzi, Tulahuén strain, T...

Tangprasittipap, A. and Prasertsan, P. 5-aminolevulinic acid from photosynthetic bacteria and its applications Songklanakarin J. Sci. Technol., 2002, 24(4) : 717-725 This paper gives an overview on ALA production by photosynthetic bacteria concerning biosynthesis and regulation as well as its application as herbicide, insecticide and growth stimulator. Recent medical applications in the field o...

BACKGROUND Corynebacterium glutamicum is generally regarded as a safe microorganism and is used to produce many biochemicals, including L-glutamate. 5-Aminolevulinic acid (ALA) is an L-glutamate derived non-protein amino acid, and is widely applied in fields such as medicine and agriculture. RESULTS The products of the gltX, hemA, and hemL genes participate in the synthesis of ALA from L-glut...

In photodynamic therapy (PDT) for cancer treatment, effective delivery of photosensitizer to the target tumor and minimal damage to the healthy cell is of paramount importance. In this study novel biocompatible positively charged (ξ = +33 mV) gold nanoparticles (30 nm average diameter) are conjugated with a photosensitizing precursor, 5-aminolevulinic acid (ALA) at physiological pH (pH 7.2 to 7...

The porphyrin and phorbin biosynthetic activity of etiolated cucumber (Cucumis sativus, L.) cotyledons was compared to that of cotyledonary homogenates. Etiolated cotyledons incubated with delta-aminolevulinic acid accumulate protoporphyrin, coproporphyrin, small amounts of Mg protoporphyrin monoester, and trace amounts of uroporphyrin. They also incorporate 4-(14)C-delta-aminolevulinic acid in...

BACKGROUND Inflammatory cells exhibit an elevated level of protoporphyrin IX (PpIX) after the administration of 5-aminolevulinic acid (ALA). Here, we investigate the sonodynamic effects of ALA-derived PpIX (ALA-PpIX) on macrophages, which are the pivotal inflammatory cells in atherosclerosis. METHODS AND RESULTS Cultured THP-1 macrophages were incubated with ALA. Fluorescence microscope and f...

The molecule 5-aminolevulinic acid (5-ALA) is a substrate for a heme synthesized in cells us‐ ing succinyl CoA and glycine. Initially, 5-ALA is converted to porphobilinogen (PBG), and the metabolism progresses by the action of PBG deaminase, and its product is incorporated into the mitochondria via uroporphyrinogen and coproporphyrinogen by an enzymatic reaction and transformed into protoporphy...