نتایج جستجو برای: 5 نیستانگاری

تعداد نتایج: 1215767  

Journal: :Development 2012
Li Tan Yujiang Geno Shi

Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine, 5mC) has emerged as an important epigenetic modification that plays essential roles in development, aging and disease. However, the mechanisms controlling 5mC dynamics remain elusive. Recent studies have shown that ten-eleven translocation (Tet) proteins can catalyze 5mC oxidation and generate 5mC deriva...

2017
Arun A. Tanpure Shankar Balasubramanian

The synthesis of 2'-O-methyl-5-hydroxymethylcytidine (hm5 Cm), 5-hydroxymethylcytidine (hm5 C) and 5-formylcytidine (f5 C) phosphoramidite monomers has been developed. Optimisation of mild post-synthetic deprotection conditions enabled the synthesis of RNA containing all four naturally occurring cytosine modifications (hm5 Cm, hm5 C, f5 C plus 5-methylcytosine). Given the considerable interest ...

2016
Andrew Sylwester Kate Z. Nambiar Stefano Caserta Paul Klenerman Louis J. Picker Florian Kern Peter Medawar

2014
Anna Chentsova Era Kapourani Athanassios Giannis

In this work we present for the first time the synthesis of novel 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) derivatives that can be used as tools in the emerging field of epigenetics for deciphering chemical biology of TET-mediated processes.

2009
Kian Peng Koh Yinghua Shen William A. Pastor Hozefa Bandukwala Yevgeny Brudno Suneet Agarwal Lakshminarayan M. Iyer David R. Liu Mamta Tahiliani L. Aravind Anjana Rao

Journal: :Clinical and diagnostic laboratory immunology 1998
M M Lesperance D G Contopoulos-Ioannidis M del Pilar Gutiérrez A M Colberg-Poley

The sensitivity and specificity of novel UL37 exon 3 (UL37x3) and US3 immediate-early (IE) gene PCR primers to detect human cytomegalovirus (HCMV) DNA in clinical specimens are comparable to those of HCMV DNA polymerase (UL54) primers. The use of these IE primers increases the diagnostic performance of HCMV PCR.

Journal: :Nucleic acids research 2004
Archna P Massey Snorri Th Sigurdsson

The chemical syntheses of RNA oligomers containing modifications on the 5'-carbon of the 5'-terminal nucleoside for crystallographic and mechanistic studies of the hairpin ribozyme are reported. Phosphoramidites 4 and 8 were prepared and used in solid phase syntheses of RNA oligomers containing the sequence 5'-N'UCCUCUCC, where N' indicates either 5'-chloro-5'-deoxyguanosine or 5'-amino-5'-deox...

2012
Marty Hinz Alvin Stein Thomas Uncini

L-5-hydroxytryptophan (5-HTP) is the immediate precursor of serotonin. It is readily synthesized into serotonin without biochemical feedback. This nutrient has a large and strong following who advocate exaggerated and inaccurate claims relating to its effectiveness in the treatment of depression and a number of other serotonin-related diseases. These assertions are not supported by the science....

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