We report a unique isoform of PLC[beta]4 in rat, PLC[beta]4c, that has an additional 37nucleotide exon inserted between nucleotides 3459-3460 of the previously published PLC[beta]4a coding sequence. This insertion results in replacement of 22 amino acid residues at the carboxyl terminal tail of PLC[beta]4a with 41 unique residues. A human EST for PLC[beta]4 also contains this exon and this exon...

A novel anionic water-soluble pillar[5]arene (4C-WP5A) was synthesized via a convenient synthetic strategy of the direct cyclization of a functionalized hydroquinone monomer. The alkyl chain dependent affinities of ferrocenyl aminiums (FCn(+), n: carbon number) with 4C-WP5A are driven by hydrophobic interactions and desolvations with assisted C-H···π interactions and electrostatic interactions.

As a partner for the DOE Metal Hydride Center of Excellence (MHCoE), GE Global Research in Niskayuna, NY developed a robust approach for metal hydride discovery as schematically shown in Figure 1. The approach is used on a daily basis at GE and it has streamlined the metal hydride discovery process. Our research allows us to investigate large numbers of compositions simultaneously, quickly scre...

In this paper we present SPADES, an interactive graphics based software package for SPA tial mechanism DES ign. The program provides a platform for the synthesis of a mechanism that guides a body through either three or four prescribed positions in space. The purpose of this work is to assemble the current spatial 4C synthesis theory into a software package that is useful for spatial mechanism ...

The effect of cancer cachexia on the oxidative metabolism of lipids has been studied in mice transplanted either with the MAC16 adenocarcinoma, which induces profound loss of host body weight and depletion of lipid stores, or the MAC13 adenocarcinoma, which is of the same histological type, but which grows without an effect on host body weight or lipid stores. While oxidation of D-[U-'4C]glucos...

We improve Chen-Ricci inequalities for a Lagrangian submanifold Mn of dimension n (n 2) in a 2n -dimensional complex space form M̃2n(4c) of constant holomorphic sectional curvature 4c with a semi-symmetric metric connection and a Legendrian submanifold Mn in a Sasakian space form M̃2n+1(c) of constant φ -sectional curvature c with a semi-symmetric metric connection, respectively.

We determined the genome sequence of industrial Saccharomyces cerevisiae strain NAM34-4C, which would be useful for bioethanol production. The approximately 11.5-Mb draft genome sequence of NAM34-4C will provide remarkable insights into metabolic engineering for effective production of bioethanol from biomass.

BACKGROUND Total body volume (TBV), with the exclusion of internal air voids, is necessary to quantify body composition in Lohman's 4-compartment (4C) model. OBJECTIVE This investigation sought to derive a novel, TBV measure with the use of only dual-energy X-ray absorptiometry (DXA) attenuation values for use in Lohman's 4C body composition model. DESIGN Pixel-specific masses and volumes w...

Introduction: The CT machine utilizes a bowtie filter to shape the X-ray beam and remove lower energy photons. Configuration of this bowtie filter is complex and its geometry is often not available in detail. It causes the CT dose index (CTDI) be with the different values in measurement versus Monte Carlo simulation studies and other analytical calculations. It is important esp...

S-1 is an oral antitumor agent that contains tegafur, which is converted to fluorouracil (5-FU) in the human body. Cytochrome P450 2A6 (CYP2A6) is the principal enzyme responsible for bioconversion of tegafur to 5-FU. A number of CYP2A6 polymorphisms have been associated with variations in enzyme activity in several ethnic populations. The CYP2A6*...