Bioactive glasses release ions such as sodium when implanted in the human body. However, an excess of released can cause problems related to cytotoxicity. The ion control is considered one primary challenges developing new bioactive glasses. Here, we use molecular dynamics simulations investigate effect density on atoms’ archetypal phosphosilicate system. diffusion coefficient displays three ma...

This study investigated the electrophoretic deposition (EPD) of the natural polymer zein combined with bioactive glass (BG) particles. Through the deposition of various BG compositions, namely 45S5 BG and Cu-doped BG, this work sought to demonstrate the ability of the films to potentiate the formation of hydroxyapatite (HA) in contact with simulated body fluid (SBF). Following incubation in SBF...

In this study, bioactive glass (BG, 45S5) particles were added to a biodegradable magnesium alloy (ZK30) through a semi-solid high-pressure casting process in order to improve the surface biocompatibility of the biomaterial and potentially its bioactivity. The observation of the as-cast microstructures of ZK30-BG composites indicated homogeneous dispersion of BG particles in the matrix. SEM, ED...

Previous studies have suggested that incorporating relatively small quantities of titanium dioxide into bioactive glasses may result in an increase in bioactivity and hydroxyapatite formation. The present work therefore investigated the in vitro bioactivity of a titanium doped bioglass and compared the results with 45S5 bioglass. Apatite formation was evaluated for bioglass and Ti-bioglass in t...

This study investigated the influence of flame spheroidisation process parameters for successfully manufacturing solid (dense) and highly porous microspheres from Food Drug Administration approved bioactive 45S5 glass with addition viscosity modifiers (i.e. 2 5 mol% borax V2O5), compared against processed phosphate (termed P40). Characterisation studies performed included thermal analysis (SDT)...

Sucrose acetate isobutyrate (SAIB) is a sugar-based carrier. We have previously applied SAIB as a minimally invasive system for the co-delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) and found synergy when co-delivering zoledronic acid (ZA) and hydroxyapatite (HA) nanoparticles. Alternative bioceramics were investigated in a murine SAIB/rhBMP-2 injection model. Neither beta...

The electrospinning technique is widely used for the fabrication of micro- and nanofibrous structures. Recent studies have focused on the use of less toxic and harmful solvents (benign solvents) for electrospinning, even if those solvents usually require an accurate and longer process of optimization. The aim of the present work is to demonstrate the versatility of the use of benign solvents, l...