pathogenic infections and inflammation are very common ailments humans suffer. upsurge of resistant pathogens has impeded the antimicrobial drug development process in recent years and the search of new antimicrobial agents is clearly evident from the literature. in line with these developments the synthesis of n-substituted aryl-2-({4-[(substituted aryl carbamoyl) methyl]-5-(pyridin-4-yl)-4h-1...

substituted 1, 2, 4- triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. these triazoles were used for preparation of different derivatives by two different schemes. in the first scheme the mannich bases were prepared from 5- marcapto-s triazole quinazolines. the 5-marcato-s-tr...

Substituted 1, 2, 4- Triazoles have shown multiple biological activities such as anti-inflammatory, anti fungal, etc. 5-mercapto triazoles were prepared from the potassium dithiocarbazinates. These triazoles were used for preparation of different derivatives by two different schemes. In the first scheme the Mannich bases were prepared from 5- marcapto-s triazole Quinazolines. The 5-Marcato-s-Tr...

Objective: To design, synthesize and in vitro anti tubercular evaluation of some new 1,2,4–triazole derivatives. Methods: Novel 1,2,4–triazole derivatives were designed by using various softwares like ACD Lab Chemsketch, Molinspiration, Prediction of activity spectra for substances(PASS) and Schrodinger Glide XP (Grid based ligand docking with energetics). The designed molecules having required...

In this communication, we introduce squaric acid derivatives as anhydrous proton conductors. We report the synthesis, characterization and proton conductivities of four squaric acid derivatives. The anhydrous proton conductivity of one of the derivatives was 2.3 × 10(-3) S cm(-1) at 110 °C, comparable to the conductivity of molten 1H-1,2,3-triazole or 1H-imidazole.

protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure to radiation. several physico-chemical and biological factors collectively contribute to the damage caused by radiation and are, therefore, targets for developing radioprotectors. chemicals capable of scavenging free radicals, relieving oxidative stress, promoting anti...

BACKGROUND 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. RESULTS This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side chain via 1,3-dipolar cycloaddition of diethylacetylene dicarboxylate with different surfactant azides. Further structural modifications of ...