Glucocorticoids induce insulin resistance in humans, whereas thiazolidinediones enhance insulin sensitivity. Although the effects of glucocorticoids and thiazolidinediones have been assessed in isolation, interaction between these drugs, which both act as ligands for nuclear receptors, has been less well studied. Therefore, we examined the metabolic effects of dexamethasone and troglitazone, al...

Thiazolidinediones (TZDs) are synthetic ligands of Peroxisome-Proliferator-Activated Receptor gamma (PPARγ). Troglitazone, rosiglitazone, and pioglitazone have been approved for treatment of diabetes mellitus type II. All three compounds, together with the first TZD ciglitazone, also showed an antitumor effect in preclinical studies and a beneficial effect in some clinical trials. This review s...

Type 2 diabetes is a common disorder with an increased risk of macrovascular complications. Achieving adequate glycaemic control is an important aim of therapy. Thiazolidinediones, or glitazones, have been used for the treatment of diabetes for a decade. Rosiglitazone and pioglitazone are currently available, however recent concerns around cardiovascular safety have led to restrictions on their...

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitu...

Thiazolidinediones (TZDs) are five-membered heterocyclic having sulfur, nitrogen, and oxygen atoms in their ring structure and exhibiting potent as well as wide range of pharmacological activities. Variety of substituents on the thiazolidine-2,4-dione nucleus or as hybrid molecules when combined with other heterocyclic rings produce wide range of biological activities suchas antihyperglycemics,...

Diabetes mellitus (DM) is one of the diseases affecting people worldwide, regardless region, race, blood type, and many more. So, management DM has been a challenging issue all over. Hyperlipidemia or Dyslipidemia main root causes DM, leading to severe cardiovascular diseases. Behavioral therapies like diet exercise can improve diabetic Dyslipidemia; however, most patients require drug therapy ...

Pyruvate is oxidized to acetyl‐CoA by pyruvate dehydrogenase which localized in the mitochondrial matrix. The carrier (MPC) composed of SLC54 family members (MPC1 and MPC2) [1, 5], form functional hetero-dimers [9, 8]. MPC expressed inner membrane involved import into mitochondria 5]. Ubiquitous disruption either MPC1 or MPC2 expression results embryonic lethality [11, 12]. Clinically relevant ...

This article gives an overview of two recent trials investigating rosiglitazone, a thiazolidinedione, in its potential to prevent type 2 diabetes (T2D) and in its effectiveness in monotherapy. Thiazolidinediones are among the most important developments of recent years for combating T2D and therefore worth to revisit. The possible influence of thiazolidines in improving beta-cell function is di...