A new series of quinazoline urea were synthesized and evaluated for antiviral and antimicrobial activity. Compound 4k [1-(2-chlorophenyl)-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea] inhibited the replication of influenza A H1N1, influenza A H3N2 and influenza B at EC50 of 0.025 μM. Compound 4e [1-(2-methyl-4-oxoquinazolin-3(4H)-yl)-3-(4nitrophenyl) urea] was found to potentially inhibits replic...

Introduction: Due to the cell labeling potentials of various metal-maltol complexes, the idea of developing a possible cell labeling imaging agent using single photon emission computed chromatography (SPECT) with[111In]-maltolate complex has been investigated. Methods: [111In] labeled 3-hydroxy-2-methyl-4H-pyran-4-onate ([111In]-maltolate) was prepared using f...

A new type of ratiometric fluorescent probe, 8-(diethylamino)-2-methyl-4-oxo-4H-pyrano[2,3-b] chromen-10-ylium tetrafluoroborate (APCT), is reported. A new type of ratiometric fluorescent probe, 8(diethylamino)-2-methyl-4-oxo-4H-pyrano[2,3-b]chromen-10-ylium tetrafluoroborate (APCT), is reported. This probe can successfully detect bisulfite anions with a detection limit of 6.1 10 7 M based on M...

New macrocyclic polyether-diester ligands (3-5) containing the 4H-pyran-4-one subcyclic unit have been prepared by treating various glycols with dimethyl chelidonate (10). In the reaction of compound 10 with ethylene glycol and diethylene glycol, two noncyclic diester and tetraester (6-9) were produced in each case. The new marcocyclic ligand 4 formed stable complexes with benzylammonium pe...