A synthetic sequence is described for construction of the tricyclic portion (35) of kempane diterpenes. The central stereochemistry was established by a Diels-Alder addition of 2,6-dimethyl-para-benzoquinone to a 5-membered, dithiane-protected diene, and the addition of acetylide, with very high chemoselectivity, provided a suitably functionalized handle that will be incorporated into the final...

BACKGROUND Conspicuous facial pores are therapeutic targets for cosmeceuticals. Here we examine the effect of topical fullerene on conspicuous facial pores using a new image analyser called the VISIA® system. Ten healthy Japanese females participated in this study, and they received applications of 1% fullerene lotion to the face twice a day for 8 weeks. FINDINGS Fullerene lotion significantl...

BACKGROUND The optimal vehicle to ensure adequate penetration of 5-aminolaevulinic acid (ALA) for its use in photodynamic therapy (PDT) of skin lesions has not been determined. OBJECTIVES We aimed to study the effects of ALA in various vehicle formulations [saline lotion with and without dimethylsulphoxide (DMSO), cream, liposomes and vaseline] after topical application in a murine subcutaneo...

Context. During the late 1990s, insecticide resistance had rendered a number of treatment products ineffective; some companies saw this as an opportunity to develop alternative types of treatment. We investigated the possibility that a surfactant-based lotion containing 10% cocamide diethanolamine (cocamide DEA) was effective to eliminate head louse infestation. Settings and Design. Initial in ...

OBJECTIVE To evaluate the clinical and hormonal response of topically applied cyproterone acetate, oral cyproterone acetate, and placebo lotion in women with acne. DESIGN Placebo-controlled, randomized study. SETTING Patients were recruited from the Institute of Endocrine Cosmetics, Vienna, Austria. PATIENTS Forty women with acne. INTERVENTIONS Treatment with oral medication consisting ...

OBJECTIVES To examine the efficacy of UV photographs and information about photoaging (eg, wrinkles and age spots) for increasing the sun protection intentions and behaviors of young adults and to determine whether any effects of this appearance-based intervention could be enhanced by providing a non-UV alternative for achieving a tan (ie, sunless tanning lotion). DESIGN Randomized control tr...

The aim of the present study was to evaluate the efficacy and safety of lignin peroxidase (LIP) as a skin-lightening agent in patients with melasma. A self-controlled clinical study was performed in 31 women who had melasma on both sides of the face. This study involved 8 weeks of a full-face product treatment. The skin color was measured at days 0, 7, 28 and 56 using a chromameter on the foreh...

gers. 4. Calculus present on sounding. Treatment.?Castor-oil 3'i.i at ni^lit. Enema of soap and water in the morning. 15tli March 1890.?Lateral lithotomy under chloroform after sounding once again, when calculus was present. The operation was straightforward and took about 15 minutes. Calculus oval in form ; yellow in colour ; flat surfaces Y x 1"; weight 30 grains composed of urates. After tre...

very irritable, and he is able to take very little nourishment. The abscess was tapped to-day, and about 4 ounces of thick pus drawn off by the aspirator: a slight return of fever in the evening. April 2nd?Again a small collection of pus was drawn off by the aspirator and weak carbolic lotion injected. 3rd.?As it was evident the abscess was not properly emptied by the tapping and aspiration, al...

BACKGROUND Treatment of head lice using physically acting preparations based on silicones is currently replacing insecticide use due to widespread resistance to neurotoxic agents. It has been postulated that some products act by asphyxiation, although the limited experimental evidence and the anatomy of the louse respiratory system suggest this is unlikely. RESULTS Observation over several ho...