The Mn(III)-initiated aerobic oxidation of heterocyclic 1,3-dicarbonyl compounds, such as 4-alkyl-1,2-diphenylpyrazolidine-3,5-diones, 1,3-dialkylpyrrolidine-2,4-diones, 3-alkyl-1,5-dimethylbarbituric acids, and 3-butyl-4-hydroxy-2-quinolinone gave excellent to good yields of the corresponding hydroperoxides, which were gradually degraded by exposure to the metal initiator after the reaction to...

The Nrf2 (NFE2L2) cell defense pathway protects against oxidative stress and disorders including cancer and neurodegeneration. Although activated modestly by oxidative stress alone, robust activation of the Nrf2 defense mechanism requires the additional presence of co-factors that facilitate electron exchange. Various molecules exhibit this co-factor function, including sulforaphane from crucif...

Dry age-related macular degeneration and Stargardt disease undergo a known toxic mechanism caused by carbonyl oxidative stresses (COS). This is responsible for accumulation in the retinal pigment epithelium (RPE) of A2E, main pyridinium bis-retinoid lipofuscin component. Previous studies have shown that stress cells could be reduced an alkyl-phloroglucinol-DHA conjugate (lipophenol). Here, we p...

Oximes are highly crystalline materials and oximation is very efficient method for characterization and purification of carbonyl compounds. These compounds not only represent a useful series of derivatives of carbonyl compounds but also may be used as intermediates for the preparation of amides by the Beckmann rearrangement [1], nitrones [2], hydroximinoyl chlorides, nitrile oxide [3] and chi a...

Oximes are known for their anti-inflammatory, antimicrobial, antioxidant, and anticancer activities. Frequently, modification of biologically active carbonyl compounds into oximes leads to increased activity. The present study reports the reactivity 2-alkanoylnaphthohydroquinones against hydroxylamine under aerial conditions. Results show that, depending on structure hydroquinones, reaction pro...

The effect of Maillard reaction on red blood cells (RBC) deformability was investigated. Exposure of RBC to carbonyl compounds (dl-glyceraldehyde, glyoxal, glycolaldehyde, 3-deoxyglucosone, and d-glucose) leading to Maillard reaction caused a marked decrease in RBC deformability even at 1mM level. The decrease rate depended on the kind of carbonyl compounds, in which both dl-glyceraldehyde and ...

The linear combination bond orbitals (L.C.B.0.) MO treatment has been used to reproduce the TI ionization energies of several ortho-, metaand para-disubstituted benzenes. The Coulomb integral of the substituent n orbitals and their resonance integrals with the ring n orbitals have been obtained from the spectra of the corresponding monosubstituted benzenes, using the same procedure for all the ...

Abstract: A rhenium complex, [ReBr(CO)3(thf)]2, catalyzed insertion of terminal alkynes into a C–H bond of active methylene sites of 1,3-dicarbonyl compounds. When a catalytic amount of isocyanide or molecular sieves was added to the reaction mixture, the reaction course changed markedly, and insertion of alkynes into a C–C single bond between αand β-positions of cyclic and acyclic β-keto ester...

Structurally different trimethyl silyl ethers are oxidized with Bu4/NIO4 in the presence of AlCl3 and BF3 as catalysts in CH3CN and CHCl3 under reflux conditions. The corresponding carbonyl compounds are isolated in good yields.