Twenty-seven patients with essential thrombocythemia were treated with combination chemotherapy consisting of weekly intravenous thiotepa (until the platelet count fell below 1,000 X 10(3)/cu mm) and daily chlorambucil (until a sustained remission, platelet count less than 400 X 10(3)/cu mm). All patients responded promptly, platelet counts fell to below 1,000 X 10(3)/cu mm by 1-3 wk, and were ...

—Retention and readability of small (2.5 3 1.0 3 0.1-mm) and large (3.0 3 1.5 3 0.1mm) visible implant (VI) tags were compared among different size-classes (211–470 mm total length, TL) of hatchery brook trout Salvelinus fontinalis. Among smaller size-groups (,400 mm TL), retention of large tags (63–86%) 100 d after tagging was less than retention of small tags (89–97%). Overall retention of la...

AIMS To evaluate the mid-term efficacy and safety of the GTS-400-iStent combined with phacoemulsification in patients with cataract and open-angle glaucoma (OAG) or ocular hypertension (OHT). METHODS Prospective, non-comparative, uncontrolled, interventional case series study. Subjects underwent phacoemulsification and two GTS-400 implantation. Efficacy outcomes: intraocular pressure (IOP) an...

BACKGROUND Cyclooxygenase-2 (COX-2) inhibitors have been shown to reduce colorectal adenomas but have been associated with increased cardiovascular risk. METHODS AND RESULTS The Adenoma Prevention With Celecoxib (APC) trial studied celecoxib 200 mg twice daily and 400 mg twice daily and the Prevention of Spontaneous Adenomatous Polyps (PreSAP) trial used 400 mg once daily totest the efficacy ...

The unidirectional digestion of DNA, first cut with two different restriction enzymes generating one 3'-protrusion and than with exonuclease III and Sl-nuclease allows a very defined removal of DNA for sequencing (1,2) or mapping of biological functions. The DNA is cloned into the polylinker of e.g. pUC18 or mpl8 (2), double digested with SstI/SmaI or PstI/XbaI, phenol extracted, ethanol precip...

c © 2009 by John von Neumann Institute for Computing Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher ment...

c © 2007 by John von Neumann Institute for Computing Permission to make digital or hard copies of portions of this work for personal or classroom use is granted provided that the copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. To copy otherwise requires prior specific permission by the publisher ment...

Near-infrared (NIR) spectroscopy has been used in studies of the cerebral hemodynamic response to visual processing. In this paper, we present theoretical results from finite element and Monte Carlo modeling in order to help understand the contribution to the NIR signal from different parts of the head. The results from the models show that at the typical optode spacings used in these studies, ...

11 12 13 14 15 16 17 18 19 PASP and BNP/NT-­‐proBNP 2 2 Summary 1 Our objective was to evaluate the utility of the natriuretic peptides BNP (brain natriuretic 2 peptide) and NT-proBNP as markers of pulmonary artery systolic pressure (PASP) in trekkers 3 ascending to high altitude (HA). 20 participants had BNP and NT-proBNP assayed and 4 simultaneous echocardiographic assessment of PASP performe...