Hexahydro-3-alkyl-3H-oxazolo[3,4-a]pyridines 4–15 for the quantitative analysis of various aldehydes were obtained in good yield via condensation reaction 2-hydroxymethylpiperidine (2-HMP) with under mild conditions. When acrolein was used, bicyclic 17 obtained. This novel compound has suitable physical characteristics an analytical standard. The hexahydro-3-vinyl-3H-oxazolo[3,4-a]pyridine 16 c...

The present work describes convenient synthesis of the novel Schiff bases 4, 5 and 6 by reaction each previously synthesized quinazolinones 1, 2 3 with p-methoxybenzaldehyde. [2+2] Cycloaddition Reaction former within phenylisothiocyanate affording azatedine derivatives 7 8. Also, quinazolines 1 could be reacted α-bromoglucose tetraacetate giving peracetylated N-glycosides 9 10 which were then ...

Carbon steel (CS) corrosion prevention is a significant problem in the industry. The development of an effective protection strategy popular research area. In this work, three thiazole derivatives (3-(2-methoxyphenyl)−4-methylthiazol-2(3H)-thione (P1), 3-phenyl-4-methylthiazol-2(3H)-thione (P2) and 3-(2-methyl-phenyl)−4-methylthiazol-2(3H)-thione (P3)) were used 0.5 M H2SO4 solution for CS miti...

The original biologically active compound (BAS) N-[2-[4-oxo-3(4H)-quinazolinyl]propionyl]-guanidine (VMA-13-15), which has cardioprotective and neuroprotective activity, was synthesized on the basis of FSUE at VolgSMU Ministry Health Russian Federation. In accordance with XIV State Pharmacopoeia Federation, one criteria for quality control pharmaceutical substances is indicator "Related Impurit...

Synthesis of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[4-(2-substitutedphenyl-4-oxo-thiazolidinyl)aryl]-6-bromo quinazolin-4(3H)ones VIa-j have been achieved from the starting material 2-[(2,6-dichlorophenyl)amino] phenylacetic acid I to benzoxazine III, Further reaction with p-phenylindiamine and substituted aromatic aldehyde gave 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-(4-aminoary...

Synthesis of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[4-(2-substitutedphenyl-4-oxo-thiazolidinyl)aryl]-6-bromo quinazolin-4(3H)ones VIa-j have been achieved from the starting material 2-[(2,6-dichlorophenyl)amino] phenylacetic acid I to benzoxazine III, Further reaction with p-phenylindiamine and substituted aromatic aldehyde gave 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-(4-aminoary...