The effects of transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) on parathyroid hormone (PTH)-responsive adenylate cyclase were examined in clonal rat osteosarcoma cells (UMR-106) with the osteoblast phenotype. Recombinant TFG-alpha and EGF incubated with UMR-106 cells for 48 h each produced concentration-dependent inhibition of PTH-responsive adenylate cyclase, wit...

introduction: neonatal jaundice has a significant prevalence, and in severe cases, causes permanent neurological sequela. many studies have carried out on neonatal jaundice and its predisposing and exacerbating factors. on the other hand, delivery method (cesarean vs vaginal) has been suggested as a predisposing factor for many of neonatal complications in many studies. the aim of this study is...

Opioids are among the oldest therapies in our armamentarium, and clinicians recognize their universal utility to limit human distress from pain. Opioids enjoy widespread use as potent analgesics, even though they are abused because of their psychoactive properties. Although the therapeutic and toxic doses are difficult to predict because of the development of tolerance with chronic use, the pri...

Incisional hernias of the abdominal wall occur in up to 11% of all other postoperative patients and in as many as 23% of patients with postoperative wound infections. Trocar site hernias after laparoscopic surgery are reported in up to 6% of patients. Parastomal hernia formation occurs in 28% of ileostomies and 48% of colostomies. Morbidity depends on the location and contents of the hernia, as...

During the British Astronomical Association (BAA) 2022 campaign, 27,436 photometric observations of dwarf nova (DN) CG Draconis were made, with 106 eclipses recorded. This work summarizes new data available and provides updated ephemeris commentary on observed eclipse profiles. The orbital period found is P orb = 4 h 31 m 38 s ± 1 $$ {P}_{orb}={4}^{\mathrm{h}}{31}^{\mathrm{m}}{38}^{\mathrm{s}}\...

The purpose of this issue of Hazard is to provide an overview of injury deaths in Victoria based on the Victorian Coroner’s Facilitation System. Although these data are not timely, they highlight outstanding causes and identify trends and changes over time to an extent unavailable from other current sources. It updates Hazard 11, June 1992 and provides an insight into the depth of timely data s...