Growth factor receptor signalling plays a central and critical role in colorectal cancer. Most importantly, the EGFR signalling cascade involving PI3K/AKT/mTOR and Raf/MEK/ERK pathways are particularly relevant, since they are commonly activated in several cancer entities, including colorectal cancer. In this study, we show that miRs-134 and -370 are both capable of regulating these pathways by...

The prevalence of cancer in antiquity is rather an unknown scientific field. Nevertheless, During the 5th century BC, Hippocrates and his followers, studied thoroughly this fatal disease and proposed surgical techniques and palliative drugs to confront and treat the malignant tumors caused by the black bile (the 4 humors theory). Inside Corpus Hippocraticum, nasal cancer was mentioned, alongsid...

Abstract Background Based on the rising detection of asymptomatic brain metastases (BM) and remarkable intracranial responses targeted- immunotherapy in specific subgroups BM patients, we aimed to evaluate clinical characteristics prognostic value neurological symptoms from melanoma. Material Methods 670 patients with newly diagnosed melanoma were identified Vienna Brain Metastasis Registry. We...

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OBJECTIVE To determine the optimal iodine concentration of contrast media for kidney multidetector computed tomography (MDCT) by comparing the degree of renal parenchymal enhancement and the severity of the renal streak artifact with contrast media of different iodine concentrations. MATERIALS AND METHODS A 16-row MDCT was performed in 15 sedated rabbits by injection of 2 mL contrast media/kg...

Objective(s): Liver transplantation is the most important therapy for end-stage liver disease and ischemia reperfusion (I/R) injury is indeed a risk factor for hepatic failure after grafting. The role of miRNAs in I/R is not completely understood. The aim of this study was to investigate the potential protective role of the mesenchymal stem cells (MSCs) and ischemic pr...

of paleohistology 369 Rehydration of desiccated tissues 370 Embedding and processing of mummified

In this paper we describe the design of the branch unit that has been implemented in some models of the recently announced IBM AS/400 1. The branch unit we describe is a modification of the unit originally designed for the experimental IBM ESA/370 2 SCISM processor. The main feature of branch unit is its capability to remove branch instructions from the instruction stream dynamically and pre-pr...

[This corrects the article on p. 370 in vol. 5, PMID: 25136345.].