Single-Nucleotide Polymorphism of rs11061971 (+219 A>T) in Adiponectin Receptor 2 (AdipoR2) Gene and its Association with Risk Type Diabetes among Iranian Population

objective(s): this study aims to investigate joint association between cholesterol ester transfer protein (cetp) polymorphisms and body mass index (bmi) or birth weight with the risk of dyslipidemia in iranian children and adolescents. materials and methods:this study was conducted as a sub-study of the “school-based nationwide health survey” (caspian-iii). we randomly selected 750 samples from...

background: endometriosis is a female health disorder that occurs when cells from the lining of the uterus grow in other areas of the body. the cause of endometriosis is unknown. objective: the purpose of this study was to investigate tp53 gene codon 72 polymorphism in women with endometriosis and compared it with healthy samples in isfahan. materials and methods: we undertook a case-control st...

background: bladder cancer is one of the most common cancers in the world with considerably higher frequency among men than women. treatment of the disease is possible according to early diagnosis, so identifying useful markers is very important. lsinct5 (long stress-induced non-coding transcript 5) is a stress-regulated lncrna involved in response to oxidative stress, also in cell proliferatio...

resistin (retn), recently found to be relevant to inflammation and inflammatory disorders. we, therefore, aimed to investigate the potential role of retn gene polymorphism in pathogenesis of acne vulgaris with familial history. we investigated the retn-420c/g polymorphism in 180 patients with acne vulgaris and 180 healthy individuals in a case-control association analysis. in this study, we als...

human serum paraoxonase (hupon1:   ec 3.1.8.1), a calcium-dependent esterase, is synthesized in the liver and   widely distributed in tissues including liver, kidney, intestine, and serum,   where it is associated exclusively with high-density lipoprotein.  human paraoxonase-1 plays an important role   in prevention of atherosclerosis and also protection against organophosphate-induced   neurot...

background: genetic variation influences susceptibility/resistance to tuberculosis. cxcl10 is involved in t-cell migration and stimulation of natural killer cells in mycobacterium tuberculosis infection. objectives: we aimed to investigate the genetic polymorphisms in promoter of the cxcl10 gene in patients with pulmonary tuberculosis (ptb) and healthy controls, to clarify whether polymorphisms...

one of the most striking features in autosomal dominant polycystic kidney disease (adpkd) is the difference at onset age of end-stage renal disease (esrd). modifier genes may play a role in this phenotypic variability. the mutated nitric oxide synthase 3 gene (nos3), have a modifier effect on the severity of adpkd by impairment of nos3 activity and decreasing of renal vascular nitric oxide prod...