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Messadi AA, Lamia T, Kamel B, Salima O, Monia M, Saida BR. Association between antibiotic use and changes in susceptibility patterns of Pseudomonas aeruginosa in an intensive care burn unit: a 5-year study, 2000-2004. Burns :J Int Soc Burn Injuries 2008;34(8):1098-102. Sherertz RJ, Sarubbi FA. A three-year study of nosocomial infections associated with Pseudomonas aeruginosa. J Clin Micr...
The aldol-Tishchenko reaction of enolizable aldehydes is a simple and effective way to prepare 1,3-diol monoesters, which are widely used as coalescing agents in the paint industry. The use of monoalcoholates of 1,3-diols as catalysts gives fast and clean reactions compared with the previous use of several inorganic catalysts. The use of the proper 1,3-diol moiety in the catalyst also reduces t...
The aldol-Tishchenko reaction of enolizable aldehydes is a simple and effective way to prepare 1,3-diol monoesters, which are widely used as coalescing agents in the paint industry. The use of monoalcoholates of 1,3-diols as catalysts gives fast and clean reactions compared with the previous use of several inorganic catalysts. The use of the proper 1,3-diol moiety in the catalyst also reduces t...
Clostridioides difficile is a Gram-positive, toxin-producing bacteria that major cause of hospital-acquired infection.1Clements A.C. et al.Lancet Infect Dis. 2010; 10: 395-404Abstract Full Text PDF PubMed Scopus (138) Google Scholar During C infection (CDI), the bacterial toxins toxin A (TcdA) and B (TcdB) are produced, which intestinal epithelial injury inflammation symptoms including diarrhea...
The clinical use of carbamazepine (CBZ), an anticonvulsant, is associated with a variety of idiosyncratic adverse reactions that are likely related to the formation of chemically reactive metabolites. CBZ-10,11-epoxide (CBZE), a pharmacologically active metabolite of CBZ, is so stable in vitro and in vivo that the potential for the epoxide to covalently interact with macromolecules has not been...
G protein-coupled receptors (GPCRs) are one of the most important classes of proteins in the genome, not only because of their tremendous molecular diversity but because they are the targets of nearly 50% of current pharmacotherapeutics. The majority of these drugs affect GPCR activity by binding to a similar molecular site as the endogenous cognate ligand for the receptor. These “orthosterical...
Flow-focusing microfluidic techniques were used to provide access to core−shell microcapsules in which the shell is composed of end-capped poly(phthalaldehydes) that depolymerize completely from head-to-tail in response to fluoride. Microcapsules made from these depolymerizable polymers provide an amplified response to the applied chemical signal, where the rate of the response can be tuned bot...
We have previously shown that inhibitors of I B kinase (IKK ), including 4(2 -aminoethyl)amino-1,8-dimethylimidazo(1,2a)quinoxaline (BMS-345541), are efficacious against experimental arthritis in rodents. In our efforts to identify an analog as a clinical candidate for the treatment of autoimmune and inflammatory disorders, we have discovered the potent and highly selective IKK inhibitor 2-meth...
ions rather than normative models, allowing reference to a more complex reality to be established for the purposes of contrast and comparison of ideas for research, in this case in the financial services sector. So, can such a framework help us analyze the implications of the GFC for SHRM and vice versa? Developments in the UK financial services sector: RBS as a case in point To assess the rele...
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