This study proposes a new concept of pH-sensitive poly(lactide-co-glycolide) (PLGA) nanoparticle composite microcapsules for oral delivery of insulin. Firstly, insulin-sodium oleate complex was prepared by the hydrophobic ion pairing method and then encapsulated into PLGA nanoparticles by the emulsion solvent diffusion method. In order to reduce the burst release of insulin from PLGA nanopartic...

The first allele of string of pearls (sop) was isolated as a recessive female sterile mutant in a P element enhancer trap screen. Oogenesis in homozygous sop females arrests at approximately stage 5. In addition, homozygous flies of both sexes have Minute-like characteristics that include reduced bristles, delayed development and larval lethality. sop maps to 30D/E on chromosome 2L and encodes ...

E-mail: [email protected] Abstract: Different dextran esters with various degrees of substitution (1, 2 and 3) were synthesized by esterification reaction, with three acid anhydrides: acetic anhydride, propionic anhydride, and butyric anhydride, separately. These modified polysaccharides were characterized by FT-IR, H NMR and C NMR spectroscopies. Enzymatic degradation of biopolymers by dextr...

Little is known about host immunodynamics during Brucellosis. We conducted immunohematological study in Brucellosis affected cattle for 3 months. Serum proteins and globulins were decreased very significantly (P<0.01) from zero day (0D) to 90D and significantly (P<0.05) from 0D to 30D. Globulins decreased significantly (P<0.05) from 0D to 75D. Titers of anti-Brucella antibodies by Standard Tube...

In the present study different regions in the scales of Channa punctatus were investigated for elemental composition to see the impact of mercury on them. Five sublethal concentrations of mercury were used after calculating the LC50 value which is 1.21mg/L in 96 hours. When focal and lepidontal regions of scales were seen under electron probe analysis (JEOL 8600M), they were composed of four ma...

Terapi farmakologi lini pertama pada pasien diabetes melitus terutama tipe II obesitas dan yang memiliki fungsi ginjal normal adalah metformin. Namun, metformin dengan sistem pelepasan segera ditemukan banyak kelemahan seperti menimbulkan efek samping rendahnya kepatuhan pasien. Untuk mengatasi hal tersebut, maka dikembangkan formulasi diperpanjang (extended release). Tujuan penulisan review ar...

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