Background—b-Blockers are the first line of therapy for hypertension. However, they are associated with side effects because of central nervous system (CNS) effects and b2-adrenergic antagonism. To overcome these problems and provide a long-term b1-blockade, antisense oligonucleotides against rat b1-adrenergic receptor (b1-AR) mRNA (b1-AS-ODN) were designed and tested for the ability to inhibit...

We evaluated whether kinins exert a protective action against the development of two-kidney, one clip (2K1C) hypertension, a model characterized by an activated renin-angiotensin system in the ischemic kidney and increased expression of the bradykinin (BK) B2 receptor in the contralateral kidney. BK B2-receptor knockout (B2-/-), wild-type (B2+/+), and heterozygous (B2+/-) mice underwent clippin...

application of bio-fertilizers, especially mycorrhiza as substituent or complement of chemical fertilizers is one of the most important strategies for plant nutrition in sustainable management of agro-ecosystems. in order to evaluate the separated and integrated application of mycorrhiza biological fertilizer and phosphorus chemical fertilizers on growth indices of chickpea (cicer arietinum l.)...

En este trabajo se presentan los resultados del análisis de un corpus compuesto 30 producciones escritas realizadas por aprendices adultos hispanohablantes ruso como LE. El objetivo es identificar errores ortográficos y sus causas en el nivel B2, así comparar número total que comenten dos grupos diferentes niveles – A2 B2. ha reflejado más frecuentes son sustitución las consonantes б-в [b]-[v],...