3-monochloropropanediol ester (3-MCPDE) is identified as a food-borne contaminant in edible oils and are classified possible carcinogen. This study reports an efficient enzymatic technique for the removal of 3-MCPDE from extra virgin olive oil (EVO) using Candida rugosa lipase (CRL) biocatalyst presence choline chloride fructose-based natural deep eutectic solvent (NADES) nanocellulose (NC) ext...

BACKGROUND When an incurable fetal condition is detected, some women (or couples) would rather choose to continue with the pregnancy than opt for termination of pregnancy for medical reasons, which, in France, can be performed until full term. Such situations are frequently occurring and sometimes leading to the implementation of neonatal palliative care. The objectives of this study were to ev...

A series of novel quinoline-3-carboxamide derivatives 10-17 and 23-27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. All of them exhibited activity against CETP. Particularly, compounds 24 and 26 displayed the best activity against CETP with the same inhibitory rate of 80.1%.

Part A I. General methods S1-S2 II. Synthesis of boronate esters (Table 1) S3-S6 III. Competition studies (Table 1) S7 IV. Synthesis of haloboronate esters (Scheme 1) S8-S13 V. Selective Suzuki-Miyaura coupling with haloboronate esters (Table 2) S14-S18 VI. Deprotection of boronate esters (Table 2) S19-S22 VII. Total synthesis of ratanhine (Scheme 3) S23-S39 Part B VIII. NMR spectra Part C IX. ...

PRAS40 binds to the mTORC1 (mammalian target of rapamycin complex 1) and is released in response to insulin. It has been suggested that this effect is due to 14-3-3 binding and leads to activation of mTORC1 signalling. In a similar manner to insulin, phorbol esters also activate mTORC1 signalling, in this case via PKC (protein kinase C) and ERK (extracellular-signal-regulated kinase). However, ...

The present communication deals with the local anesthetic activity and toxicity of 16 basic alkyl esters of substituted pyrrolidine dicarboxylic acids.t In an accompanying article5 the intestinal, uterine, and depressor activity of these compounds is presented. Twelve of the compounds were 2, 5-di-(3-diethylaminoethyl) esters and 3 were 2, 5-di-(y-diethylaminopropyl) esters. One was 2-(Zdiethyl...

A new approach for the synthesis of 4-oxo-3-quinolinecarboxylic acid derivatives is described. This methodology involves the C-acylation of the anions of appropriate beta-keto esters with novel N-hydroxysuccinimide esters of anthranilic acids. The intermediate C-acylation products 3 are spontaneously cyclized to afford 3-ethoxycarbonyl-4-oxoquinoline derivatives 4. The introduction of a variety...

The chemical synthesis and properties of L-carnitine esters of P-ketopalmitic acid, /3-hydroxypslmitic acid, and ~ranstr,P-unsaturated palmitic acid are described. Isolated rat liver mitochondria oxidize the carnitine esters of these acids more efficiently than the free acids as judged by acetoacetate production and oxygen uptake. Rat liver mitochondrial extracts catalyze the conversion of palm...

We describe the use of HPLC with muitiwavelength detection to measure retinol, a-tocopherol, Iutein/zeaxanthin, f3-cryptoxanthin, lycopene, a-carotene, trans-p-carotene, /3-carotene, and the linoleate, oleate, palmitate, and stearate esters of retinol in a single 200L serum sample. The method is sensitive enough to detect individual retinyl esters in fasting serum from a nonhyperlipidemic popul...