Tissue phantom ratio (TPR), for square fields of various dimensions has been determined at varying depths in water. The dose in water has been measured at a fixed source-to-surface distance (SSD) of 100 cm and reference depth of 5 cm for 6 MV photon beam of Siemens Linear Accelerator Primus 11 in German Cancer Research Center (DKFZ), Heidelberg, Germany. A modified formula has been developed to...

The incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), play an important role in glucose homeostasis in both health and diabetes. In mice, sucralose, an artificial sweetener, stimulates GLP-1 release via sweet taste receptors on enteroendocrine cells. We studied blood glucose, plasma levels of insulin, GLP-1, and GIP, and gastric emptying ...

A small animal positron emission tomography (PET) instrument using a high-resolution solid-state detector insert in a conventional PET system was investigated for its potential to achieve sub-millimeter spatial resolution for mouse imaging. Monte Carlo simulations were used to estimate the effect of detector configurations (thickness, length and radius) on sensitivity. From this initial study, ...

The pharmacology of the large-conductance K(+) (BK) channel in human osteoblasts is not well defined, and its role in bone is speculative. Here we assess BK channel properties in MG63 cells and primary human osteoblasts and determine whether pharmacological modulation affects cell function. We used RT-PCR and patch-clamp methods to determine the expression of BK channel subunits and cell number...

A new type of apparatus for the production of single bubbles of adjustable size is presented. A single bubble is generated by injecting a short burst of gas into a liquid channel flow. The radius of the bubble can be varied continuously from 300 mm up to a 3 mm by adjusting the timing of a valve injecting the gas. The device works also in liquids with variable pressure and can be microcomputer ...

Photodynamic therapy (PDT) is an increasingly popular anticancer treatment that uses photosensitizer, light and tissue oxygen to generate cytotoxic reactive oxygen species (ROS) within illuminated cells. Acting to counteract ROS-mediated damage are various cellular antioxidant pathways. In this study, we combined PDT with specific antioxidant inhibitors to potentiate PDT cytotoxicity in MCF-7 c...

Bu çalışma; aspir çeşitlerinin çimlenme ve çıkış dönemlerinde tuz (NaCl) stresine karşı tepkilerini belirlemek amacıyla yürütülmüştür. Denemede Asol, Balcı, Dinçer, Linas Olas çeşitleri materyal olarak kullanılmıştır. Araştırmada tohumlarına döneminde saf su (kontrol) ile 3 farklı NaCl (100 mM, 200 mM 300 mM) dozu uygulanmıştır. Çimlenme denemesi, petri kaplarında tesadüf parselleri faktöriyel ...