New chiral camphane-derived benzisoselenazol-3(2H)-ones and corresponding diselenides have been synthetized using a convenient one-pot procedure. Se-N bond was efficiently converted to an Se-Se bond, which could also be easily re-oxidized to the initial benzisoselenazolone moiety. The antioxidant activity of camphor derivatives was evaluated and compared to the reactivity of a series of N-amino...

New coumarin derivatives, namely (2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-phenylthiazolidin-3-yl)acetamide, N-(2-(3-methoxyphenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide, 2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-N-(4-oxo-2-(2,3,4trimethoxyphenyl)thiazolidin-3-yl)acetamide and N-(2-(4-bromophenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)ac...

an efficient construction of 2-(n-arylamino)benzaldehydes and n-aryl-3,10-dihydroacridin-1(2h)-one derivatives starting from 2- hydroxybenzaldehydes has been developed. the synthesis of n-aryl-3,10-dihydroacridin-1(2h)-ones is based on the knoevenagel condensation of dimedone to various 2-(n-arylamino)benzaldehydes, followed by an intramolecular enamination in the presence of 20 mol% of nanocry...

Perdeuteration of biological macromolecules for magic angle spinning solid-state NMR spectroscopy can yield high-resolution (2)H-(13)C correlation spectra and the method is therefore of great interest for the structural biology community. Here we demonstrate that the combination of sample deuteration and dynamic nuclear polarization yields resolved (2)H-(13)C correlation spectra with a signal e...

A decrease in methanogenesis is expected to improve ruminant performance by allocating rumen metabolic hydrogen ([2H]) to more energy-rendering fermentation pathways for the animal. However, decreases in methane (CH4) emissions of up to 30% are not always linked with greater performance. Therefore, the aim of this study was to understand the fate of [2H] when CH4 production in the rumen is inhi...

Using first-principle calculations, we characterize the properties of N-confused porphyrins (NCP), with a focus on the differences between the 2H and 3H tautomers. We find that NCP-3H is almost as strongly aromatic as porphyrin, and about twice as aromatic, i.e., remarkably more stable, than NCP-2H, due to the less efficient π-conjugation in the latter form. The deprotonation of the NH-group at...

Establishing a simple yet reliable compost stability test is essential for a better compost quality control and utilization efficiency. The objective of this study was to examine the relationship between extractable organic carbon (OC) and compost stability based on 18 compost samples from five composting facilities. The compost samples were extracted sequentially with water for 2 h [water(2h)]...

The early adoption of digital health solutions in the treatment growth disorders has enabled collection and analysis more than 10 years real-world data using easypod™ connect platform. Using this rich dataset, we were able to study impact engagement on three key treatment-related outcomes: adherence, persistence use, growth. In total, for 17,906 patients available. features, regularity injectio...

(+)-2,5-Bis[4’-((S)-2-methyl butyoxy)phenyl]toluene (3a): 0.048 mol (10 g) 4-[(S)-2-methyl butoxyl]phenylboronic acid dissolved in 20 ml of ethanol is added dropwise to the mixture of 0.02 mol (5 g) of 2,5-dibromotoluene, 0.8 mmol (0.924 g) tetrakis(triphenylphosphine)palladium Suzuki cross-coupling catalyst, 20 ml of benzene, 40 ml of ethanol, and 60 ml of 2M Na2CO3 aqueous solution under argo...