The homeodomain is a DNA-binding motif present in a large number of eukaryotic transcription factors. To date, over 1,000 homeodomain proteins from over 100 different organisms have been described, making this family of DNA binding proteins one of the largest in biology (Banerjee-Basu et al., 1999; Banerjee-Basu et al., 2000; Gehring et al., 1994). Many homeodomain-containing factors, such as m...

ÐA variety of new chiral phosphoramidites was synthesised and tested in the copper-catalysed enantioselective conjugate addition of diethylzinc to cyclohexenone and chalcone in order to assess the structural features that are important for stereocontrol. A sterically demanding amine moiety is essential to reach high e.e.'s. Enantioselectivities for chalcones up to 89% and for cyclic enones up t...

Staphylococcus aureus is the most common pathogen involved in skin and soft tissue infections, and it is the principal cause of surgical site infections (1–3). Most of the laboratory methods for detecting S. aureus and methicillin-resistant S. aureus (MRSA) from wounds require incubation time and do not support rapid decisions for selection of the most appropriate procedural or therapeutic inte...

84, 2865]. Abstraction [1586, 2908, 2138]. abstractions [2909]. abundant [1786]. Abuse [604, 601]. academia [2337, 1105, 1155]. Academic [1919, 15, 1405, 1714, 2639, 248, 1972, 1295, 1945, 2990]. academics [378]. Accelerating [682, 2310]. Acceptable [607]. acceptance [934, 2590, 1448]. Access [2484, 258, 397, 376, 541, 588, 1409, 2454, 183, 699, 2596, 990, 1273, 2, 898, 1977, 705, 2718, 2819, 1...

Background SERENA is an ongoing, longitudinal, observational study of more than 2900 patients (pts) with moderate to severe psoriasis, active psoriatic arthritis (PsA), and ankylosing spondylitis (AS) conducted at 438 sites across Europe expected duration up 5 years. 1,2 Objectives We report long-term results (at least 3 years follow up) on secukinumab (SEC) retention, effectiveness safety in p...

See related article, pages 2957–2962 Computerized clinical decision support systems are increasingly popular in health sciences and have been demonstrated to improve practitioner performance.1 For an emergency closely related to ischemic stroke, acute myocardial infarction, a thrombolytic predictive instrument was developed for real-time use in emergency medical-service settings to identify pat...

T lifetime prevalence of headache is 93% for men and up to 99% for women.1 The public health significance of headaches is often overlooked, probably due to their episodic nature and lack of mortality, but headache disorders are often incapacitating, with considerable impact on social activities and work, and may lead to significant drug consumption.2 The socio-economic burden of headache includ...

See related article, pages 2860–2865. Antihypertensive treatment is accepted as the most effective means for preventing stroke, and its effectiveness is solidly founded on a series of large randomized controlled trials.1,2 Hypertension experts can be proud that antihypertensive therapy has been the first among cardiovascular therapies that has been tested by randomized controlled trials using s...

Introduction Estrogen receptor (ER) status has been used in the clinical management of breast cancer both as a predictive factor for treatment and as a prognostic factor for survival. Compared with ER-positive cancer, ER-negative cancer has a poorer clinical outcome and shorter median survival [1, 2]. ER-negative cancer was more aggressive, with bigger tumor size, more prominent tumor infiltrat...