Mdm2 is the main regulator of p53 and is amplified in approximately 7% of all human cancers. MDM2 gene amplification as well as expression has been correlated to an increased tumorigenic potential. We have analyzed the prevalence of MDM2 gene amplifications and SNP309 in 284 colorectal tumors using a relatively new highly sensitive PCR/ligase detection reaction method in relation to TP53 mutati...

1 Stress in Vivo 2 3 Running Title: Vasoprotective Effects of the HO System 4 5 Lu Kang, Matthew L. Hillestad, Joseph P. Grande, Anthony J. Croatt, Michael A. Barry, 6 Gianrico Farrugia, Zvonimir S. Katusic, and Karl A. Nath 7 8 Division of Nephrology and Hypertension; Division of Cardiovascular Disease; Department of 9 Laboratory Medicine and Pathology; Division of Infectious Diseases; Divisio...

INTRODUCTION 272 CLINICAL ASPECTS OF OBESITY AND CARDIOMETABOLIC DISEASE 273 Background – Do We Need Drugs for Obesity? 273 Current Drugs for Obesity and Their Limitations 274 Other Drugs – Withdrawn or No Longer Recommended for Routine Clinical Use 275 The Need for New Drugs 275 BIOLOGY AND GENETICS OF ENERGY REGULATION AND IMPLICATIONS FOR OBESITY 276 Short-Term (Episodic) Signals 276 Meal On...

BACKGROUND Most adults in primary care are overweight or obese; two thirds of patients with weight problems have other obesity-related conditions. The study objective was to explore the feasibility of a primary care obesity intervention based on the transtheoretical model (TM) of behavior change and principles of chronic disease (CD) care. METHODS A prospective study of the initial version of...

Since November 1982 at the Sainte-Justine Hospital in Montreal, ampicillin and cefotaxime were used in association as initial treatment (greater than or equal to 48 h) for childhood bacterial meningitis. In this report is described the in vitro interaction of the new regimen in comparison with that of the previous ampicillin-chloramphenicol combination against 284 Haemophilus isolates. Among th...

The landmark paper by Hirose et al. (Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M., Science 284:1527-1530, 1999) presented experimental investigations to show that not only can calcium upregulate IP(3), but that it can also have an inhibitory effect on IP(3). In this paper, we present a preliminary model, which is consistent with these experiments. This model includes positive a...

This paper proposes a data reduction and hypothesis testing methodology that can be used to perform hypothesis testing with data commonly collected in benchmarking studies. A reduced-form performance vector and a reduced-form set of decision variables are constructed using the multivariate data reduction techniques of principal component analysis and exploratory factor analysis. Reductions in d...