BACKGROUND There is little information about the risk of stroke in relation to time since initiation of hormone therapy and in relation to estrogen dose. METHODS We conducted a population-based case-control study at Group Health Cooperative (GHC), a health maintenance organization in the greater Seattle (Wash) area, to assess the association of hormone replacement therapy with the risks of in...

This article describes an implementation of real-time simulation and control in DEVS-Scheme, a knowledge-based, discrete event environment. We illustrate a methodology in which the plant, its actuators and sensors are described by discrete event models developed within the event-based control paradigm. A model of the controller is employed to validate its design in a plant/actuator/sensor exper...

OBJECTIVE To evaluate the efficacy of NESTROFT (Naked Eye Single Tube Red Cell Osmotic Fragility Test) as a screening tool for detection of beta thalassemia trait. DESIGN Prospective study. SETTING Field camps in various parts of Gujarat and Maharashtra States. METHODS A total of 2525 subjects were screened. NESTROFT, complete hemogram including red cell indices and calculation of Mentzer...

This article highlights trends in heart transplantation from 1998 to 2007, using data from the Organ Procurement and Transplantation Network (OPTN) and the Scientific Registry of Transplant Recipients (SRTR). The number of candidates actively awaiting heart transplantation has declined steadily, from 2525 in 1998 to 1408 in 2007, a 44% decrease. Despite this decline, a larger proportion of pati...

Wong S, Gardner AB, Krieger AM, Litt B. A stochastic framework for evaluating seizure prediction algorithms using hidden Markov models. J Neurophysiol 97: 2525–2532, 2007. First published October 4, 2006; doi:10.1152/jn.00190.2006. Responsive, implantable stimulation devices to treat epilepsy are now in clinical trials. New evidence suggests that these devices may be more effective when they de...

M. E. S. Bracken ([email protected]), Dept of Ecology and Evolutionary Biology, Univ. of California, Irvine, CA 93923-2525, USA. – H. Hillebrand, Inst. for Chemistry and Biology of the Marine Environment (ICBM), Carl-von-Ossietzky Univ. Oldenburg, Schleusenstrasse 1, DE-26382 Wilhelmshaven, Germany. – E. T. Borer and E. W. Seabloom, Dept of Ecology, Evolution and Behavior, Univ. of Minnesota, M...

Movement of T-lymphocyte cell surface CD43 is associated with both antigen activation of T-cell clones and chemokine induction of T-lymphocyte motility. Here, we demonstrate that CD43 movement away from the site of T-cell receptor ligation occurs in unprimed CD41 T cells as well as T-cell clones. The T-cell receptor (TCR)-dependent movement of CD43 in unprimed T cells is associated with a polar...

PURPOSE To examine the relationship of central corneal thickness (CCT) with optic disc parameters measured by confocal scanning laser ophthalmoloscopy in a Malay population. METHODS This was a population-based cross-sectional study of Asian Malay adults aged 40-80 years living in Singapore. Participants had a standardized interview, examination, and imaging at a study clinic. CCT was measured...

BACKGROUND/AIMS We used a simulation model of statistical analysis to estimate the cost and procedural burden of colorectal cancer (CRC) screening and surveillance using colonoscopy. METHODOLOGY The estimated financial resources have been evaluated by multiplying half of the scheduled colonoscopies with the cost of one surveillance colonoscopy, dividing the result to the median time in which ...

BACKGROUND AND PURPOSE Arterial spin-labeling MR imaging permits safe, repeated CBF measurement. We investigated the potential and technical factors of arterial spin-labeling imaging in assessing cerebrovascular reactivity to acetazolamide. MATERIALS AND METHODS The regional CBF was measured in 8 healthy volunteers by use of a 3D pseudocontinuous arterial spin-labeling sequence. Arterial spin...