In just 10 years from its discovery in 2000, interleukin-23 has quickly moved from being recognized as a pro-inflammatory cytokine to a key player and potential therapeutic target in psoriasis.

Several derivatives of 5-O-mycaminosyltylonolide substituted at C-23 have been prepared; these are 23-deoxy-23-C-methylene (3), 23-deoxy-23-C-(methoxycarbonylmethylene) (5), 23-deoxy-23-C-(ethoxycarbonylmethylene) (7), and 23-deoxy-23-C-(butoxycarbonylmethylene) (9), 23-deoxy-23-C-[(2E)-3-(ethoxycarbonyl)-2-propenylene] (11), and 23-deoxy-23-(dimethylaminoimino) (13), and 14-de(hydroxymethyl)-1...

Case name: Doe v. Haverford College, No. 23‐299 (E.D. Pa. 02/14/23).

The recent advances in the understanding of psoriasis pathogenesis have clarified the pivotal role of interleukin (IL)-23. It is a heterodimeric cytokine consisting of two subunits, the unique p19 and the p40, which are shared with IL-12. The basic role of IL-23 in psoriasis is the activation and maintenance of the T-helper 17 pathway. New research findings indicate that IL-23 is more important...

3,4-dihydropyridin-2-ones are of considerable importance due to the large number these core structures exhibiting a diverse array biological and pharmacological activities. The Michael-type addition 1,3-dithiane-2-carbothioates α,β-unsaturated N-tosyl imines, followed by intramolecular annulation driven sulfur leaving group, provides practical reaction cascade for synthesis variety substituted ...

The asymmetric unit of the title compound, C(9)H(14)OS(4), comprises two crystallographically independent mol-ecules with similar conformations. In each mol-ecule, an intra-molecular C-H⋯O hydrogen bond generates a six-membered ring, producing an S(6) ring motif. All of the six-membered dithia-cyclo-hexane rings adopt chair conformations. The crystal structure is stabilized by four inter-molecu...

Self-assembly and aggregation of amyloid peptides, such as Aβ(1-40) and Aβ(1-42), lead to the development of Alzheimer disease and similar neurodegenerative disorders associated with protein aggregation. The structures of large aggregates, specifically fibrils, are well characterized. However, our understanding about the structure of oligomeric forms of amyloids is incomplete and needs to be ex...

Electrode potential of 2-(2,3-dihydroxy phenyl)-1,3-dithiane (DPD) was investigated by means of cyclic voltammetry (CV) at various potential scan rates. The calculated value was compared with the experimental value obtained by cyclic voltammetry (CV). All experiments were done in aqueous phosphate buffer solutions at different pHs. The experimental redox potential of DPD was obtained to be 0.75...