نتایج جستجو برای: 225
تعداد نتایج: 11288 فیلتر نتایج به سال:
Human peripheral blood lymphocytes can be phenotypically identified by the presence of one or both of two proteins, 225,000-dalton macromolecular insoluble cold globulin (225-MICG) and 185,000-dalton MICG (185-MICG). T cells synthesize and insert into their plasma membrane 225-MICG, null cells 185-MICG, and B cells both 225 and 185-MICG. In contrast, the monoclonal B cells of chronic lymphocyti...
Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis. It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling pathways are aberrantly reactivated in pancreatic CSCs. Here, we examined the efficacy of combining NVP-LDE-225 (PI3K/mTOR inhibitor) and NVP-BEZ-235 (Smoothened inhibitor) on pancreatic CSCs characteristics, microR...
Antibodies reactive with human epidermal growth factor receptor (EGFr), such as 225 IgG1 (Masui et al., Cancer Res., 44: 1002-1007, 1984), are effective tumor-suppressive agents in xenograft models. In the present study an additional antibody reactive with EGFr was made and compared to 225 IgG1 for antitumor activity as an unmodified antibody or as a drug immunoconjugate. This IgG1 clone, desig...
Radium needles that were once implanted into tumours as a cancer treatment are now obsolete and constitute a radioactive waste problem, as their half-life is 1600 years. We are investigating the reduction of radium by transmutation on a small scale by bombarding Ra-226 with high-energy photons from a medical linear accelerator (linac) to produce Ra-225, which subsequently decays to Ac-225, whic...
Ana Sofia Correia1,2, António J. Madureira3, Alexandra Gonçalves1,2*, Pedro Bernardo Almeida1,2, and Vı́tor Araújo1 Cardiology Department, Centro Hospitalar de São João, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal; Cardiology Department, University of Porto Medical School, Porto, Portugal; and Radiology Department, Centro Hospitalar de São João, Porto, Portugal * Corresponding autho...
RESEARCHDESIGNANDMETHODSdPatients inadequately controlled onmetformin and sulfonylurea (HbA1c $7 to #10%) were randomized and treated with once-daily empagliflozin 10 mg (n = 225), empagliflozin 25 mg (n = 216), or placebo (n = 225) for 24 weeks. The primary end point was change from baseline inHbA1c at week 24. Key secondary end points were changes from baseline in weight and mean daily glucos...
Morgan W. Kelly1*, Jacqueline L. Padilla-Gamiño2, and Gretchen E. Hofmann3 Department of Biological Science, Louisiana State University, Baton Rouge, LA 70803, USA Department of Biology, California State University, Dominguez Hills, Carson, CA, USA Ecology, Evolution, and Marine Biology, University of California, Santa Barbara, Santa Barbara, CA, USA *Corresponding author: tel: + 1 225 578 0224...
(a) Perform a principal components analysis of this dataset on both the covariance and correlation matrices, reporting both estimated variances and loadings. Why are the results different? Why does PCA on the correlation matrix make more sense for this data? The remaining parts assume that you use PCA on the correlation matrix. Solution: The results are different because PCA is not scale invari...
We report on a search for particle dark matter with the XENON100 experiment, operated at the Laboratori Nazionali del Gran Sasso for 13 months during 2011 and 2012. XENON100 features an ultralow electromagnetic background of (5.3 ± 0.6) × 10(-3) events/(keV(ee) × kg × day) in the energy region of interest. A blind analysis of 224.6 live days × 34 kg exposure has yielded no evidence for dark mat...
S OF PHD THESES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EATCS LEAFLET . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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