MicroRNAs (miRNAs) are small non-coding RNAs that are key post-transcriptional regulators of gene expression. MicroRNA-214 (miR-214) and microRNA-218 (miR-218) have shown the function of tumor suppressors in various types of human cancers. However, the biological functions of miR-214 and miR-218 in breast cancer have not been elucidated completely. The present study evaluated the expression and...

Proposal for Construction of a Physical Map of the Genome of the Zebra Finch (Taeniopygia guttata) 9 January 2005 Proposal submitted by: David Clayton, Ph.D., Professor Cell & Structural Biology, Neuroscience Member, Institute for Genomic Biology B107 Chemical & Life Sciences Laboratory University of Illinois Urbana, Illinois 61801 phone 217-244-3668, fax 503-213-6611 [email protected] http://w...

Previous studies showed that microRNA-214 (miR-214) may act as a prognostic biomarker of cancer. However, the available evidence is controversial. This study summarizes evidence and evaluates the prognostic role of miR-214 in various cancers. We carried out a systematic literature review and assessed the quality of included studies based on Oxford Centre for Evidence-based Medicine Criteria and...

INTRODUCTION ............................................................. 198 CELLULAR LIPIDS ......................................................... 198 Extraction .................................................................. 198 Subcellular Distribution .................................................... 198 Cytoplasmic (plasma) membrane .......................................... 198...

Several years ago the distributions of the ridge-counts on all ten fingers were given for a small sample of unrelated persons (Holt, 1949). A more detailed analysis has recently been made of the digital counts of a population sample of 1650 persons, 825 males and 825 females, and the results are given here. Included in the sample are the 100 males and 100 females whose counts were used previous...

Du sequentiel au parallele: la recherche aborescente a la programmation quadra-tique en variables 0 et 1, 1987. Th ese d'Etat. 33] , A parallel branch and bound algorithm for the quadratic assignment problem, Discrete A GRASP FOR QAP 21 4. Concluding remarks. In this paper, we discussed aspects of a GRASP implementation for solving the QAP. The algorithm was tested on a broad range of test prob...

Objective: To assess the influence of pharmacists’ opinions on their dispensing medicines with a «medical prescription only» label without requiring a doctor’s prescription. Methods: We performed a cross-sectional study of 166 community pharmacies in northwest Spain. The opinions of pharmacists on the following were collected as independent variables through personal interview: a) physicians’ p...

BACKGROUND Recent studies have emphasized causative links between microRNAs (miRNAs) deregulation and tumor development. In hepatocellular carcinoma (HCC), more and more miRNAs were identified as diagnostic and prognostic cancer biomarkers, as well as additional therapeutic tools. This study aimed to investigate the functional significance and regulatory mechanism of the miR-199a2/214 cluster i...

This paper argues that morality is required to allow the gains from trade to be reaped by reducing the ‘policing’ type of transactions costs involved in opportunistic behaviour. But, as Hume emphasised neither God nor Reason can justify any particular morality, the only source of morality must be local traditions which socialize children through the moral emotions of shame and guilt. Capitalism...