Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability counter the effects topoisomerase (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monoterpenoid residues connected via 1,2,4-triazole or 1,3,4-thiadiazole linkers were synthesized tested against Tdp1. All derivatives exhibited inhibition a...

The research is a vision of the future industry in Iraq, so it may be outside ceiling capabilities Iraqi economy, and therefore exaggerated. Therefore, plans must applicable through availability capabilities. Everyone knows that financial administrative corruption mismanagement resources are main cause inefficiency industrial sector, failure to exercise its real role achieving economic developm...