Benzimidazole, a simple heterocycle continues to hold promise to medicinal chemists. A vast number of compounds contain this scaffold and many of these have become blockbusters such as omeprazole, astemizole, candesartan to name a few. Benzimidazoles are unique in that they have been reported to show activity against fungal, mammalian and helminthes cells via binding to microtubules. They are t...

was proportional to the acidity of the imidazole -NH group. Tetrachloro-2trifluoromethylbenzimidazole was the most active (50% uncoupling of oxidative phosphorylation at 7-9 x 10-8M, pK5.04). Nitro-substituted analogues were less active than predicted from pK considerations or from partition-coefficient measurements. 3. Introduction of an -NH2 or -CO2H substituent caused a loss of uncoupling ac...

In the title compound, C(12)H(13)N(3)O(2)S, the oxazolidin ring displays an envelope conformation. The dihedral angle between the benzimidazole ring and the 1,3-oxazolidin-2-one mean plane is 69.85 (13)°. In the crystal, mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds, forming a chain parallel to the b axis.

A novel approach was applied to synthesize silver nanoparticles using starch under sonication. Colloidal silver nanoparticles solution exhibited an increase of absorption from 420 to 440 nm with increase starch quantity. Transmission electron microscopy followed by selected area electron diffraction pattern analysis indicated the formation of spherical, polydispersed, amorphous, silver nanopart...

A series of 2-(substituted phenyl)-1H-benzimidazole (1-10) and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanone (11-19) derivatives were synthesized and tested in vitro for their antimicrobial activity. The results of QSAR investigation indicated the importance of molecular descriptors, dipole moment (mu), log of octanol water partition coefficient (logP) and second order molec...

In this paper, a bimetallic Metal-Organic Framework (MOF) CoNiBTC was employed as precursor for the fabrication of nanoalloys CoNi@C evenly disseminated in carbon shells. These functional nanomaterials are characterized by powdered X-ray diffraction (PXRD), Fourier Transform Infra-Red spectroscopy (FTIR), surface area porosity analyzer, photoelectron (XPS), Field emission scanning electron micr...