there exists compelling evidence that toll-like receptor 3 (tlr3) agonists can directly affect human cancer cells. the aim of this study was to investigate anti-cancer effects of tlr3 agonist in human breast cell line. we assessed potential effects of poly (a:u) on human breast cell line (mda-mb-231)  on a dose-response and time-course  basis. human breast cell line  mda-mb-231  was treated wit...

Purpose: The aim of this study is to explore the effects gossypin on matrix metalloproteinases -2 (MMP-2) and MMP-9 genes in prostate cancer cells. Materials Methods: PC3 cells were grown culture treated with three different concentrations (25-50-100 µg/ml) cisplatin (50 µM) as a positive control. First, RNA isolation was performed. Then, cDNA synthesis performed RT-PCR used evaluate mRNA expre...

Background & objective: Pruritus is the most frequent chronic dermal complication of sulfur mustard (SM), which negatively influences the quality of life. Exact pathophysiology of SM-induced itching is unknown. The current study aimed at evaluating the possible association between SM-induced itching and the serum levels of matrix metalloproteinase (MMP...

The interest taken in studying pathomorphological and pathophysiological mechanisms behind periodontal inflammation affecting children with undifferentiated connective tissue dysplasia (UCTD) can be accounted for by the disease high prevalence, risk of its progression, as well morphological functional immaturity tissues low effectiveness available treatment options. study into matrix metallopro...

Abstract Background The aim of this study was to determine the temporal evolution extracellular matrix (ECM) remodelling and collagen biomarkers their influence on incisional hernia recurrence after IPOM plus repair. Methods A sub-cohort patients (n=25) undergoing laparoscopic repair within TACKoMesh randomised controlled trial were bled at serial timepoints up 1-year following surgery. Serum/p...

ObjectiveThe aim of this study was to observe the spatial distribution and dynamic changes matrix metalloproteinase (MMP)-2, MMP-9, collagen in stent restenosis (ISR) explore their influence on ISR.MethodsSixty Z type stents were implanted into common iliac arteries minipigs, which divided 10 groups (six each group) according euthanasia time (6 hours, 1, 3, 7, 14, 28, 56, 84, 168, 336 days). Af...

Matrix metalloproteinases (MMPs) are a family of zinc-dependent enzymes capable of degrading extracellular matrix components. Previous studies have shown that the upregulation of MMP-2 is closely related to metastatic cancers. While Western blotting, zymography, and Enzyme-Linked Immunosorbent Assays (ELISA) can be used to measure the amount of MMP-2 activity, it is not possible to visualize th...