In the presence of MnCl2 and a thiol (glutathione, cysteine, 2-nitro-5-thiobenzoic acid) horse radish peroxidase oxidizes p-hydroquinone to p-benzoquinone which in turn immediately adds the thiol present yielding 2-S-substituted p-hydroquinone.

The paper reports a facile synthesis of novel anionic spherical polymer brushes which was based on grafting sodium 2-acrylamido-2-methylpropane-1-sulfonate from the surface 4,4′-Azobis (4-cyanopentanoyl chloride)-modified carbon spheres. Various characterization methods involving scanning electron microscope, energy dispersive X-ray spectroscopy, Fourier transform infrared spectrum, and thermo-...

To improve the corrosion protection of copper metal, 0.01M concentration of 1H-1,2,4-triazole-3-thiol (TAT) was incorporated into the hybrid sol-gel monolayers containing 3-glycidoxypropyltrimethoxysilane (GPTMS) and Tetraethoxysilane (TEOS). It was further subjected to hydrolysis and condensation reaction to form a sol-gel matrix. The TAT-doped hybrid sol-gel coating was applied over the c...

Reactions of benzoylpyruvate with a mixture of aromatic aldehydes and 5-amino-1,3,4-thiadizole-2-thiol in a 1:1:1 molar ratio, afforded 5-(5-aryl-4-benzoyl-3-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-1,3,4-thiadizole-2-thiols (3a-c). The structure of the resulted products was confirmed by determination of the melting point and spectrophotometric techniques such as IR and 1H-NMR spectroscopy.

Hydrogen peroxide is thought to regulate cellular processes by direct oxidation of numerous cellular proteins, whereas antioxidants, most notably thiol peroxidases, are thought to reduce peroxides and inhibit H(2)O(2) response. However, thiol peroxidases have also been implicated in activation of transcription factors and signaling. It remains unclear if these enzymes stimulate or inhibit redox...

Seven new cyclic natural polysulfides 1-7 were identified in extracts of two bacterial Cytophaga strains (CFB-phylum) isolated from biofilms from the North Sea. Their structures are based on mono- and dimeric-cyclization products of 2-methylpropane-1,2-dithiol 8, which was also present in the extract in trace amounts. The structures were deduced by analysis of their mass spectra and confirmed b...

A small-molecule cysteine sulfenic acid (Cys–SOH) with ‘shelf stability’ protected by a molecular cradle was synthesized direct oxidation of thiol H2O2. Its crystal structure and biologically relevant reactivity were elucidated.

The neuroimmunodegenerative syndrome that develops in mice infected with ts1, a mutant of Moloney murine leukemia virus, resembles human AIDS. Both ts1 and human immunodeficiency virus type 1 infect astrocytes, microglia, and oligodendrocytes but do not infect neurons. Oxidative stress has been implicated in the neuropathology of AIDS dementia and other neurodegenerative diseases. We report her...