Lutz, Peter L., and Liscia Manuel. Maintenance of adenosine A1 receptor function during long-term anoxia in the turtle brain. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R633–R636, 1999.—It has been established that adenosine has a critical role in the extraordinary ability of the turtle brain to survive anoxia. To further investigate this phenomenon we compared rat and turt...

Doughty, Joanne M., Frances Plane, and Philip D. Langton. Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1107–H1112, 1999.—In rat mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF) is blocked by a combination of apamin and charybdotoxin (ChTX). The site of action of these t...

Oyekan, A. O., K. McAward, J. Conetta, L. Rosenfeld, and John C. McGiff. Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCAsalt hypertension. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R766–R775, 1999.—Inhibition of cytochrome P-450 (CYP450) enzymes with cobalt chloride (CoCl2) prevented hypertension, organ hypertrophy, and renal inju...

Khan, Janine Y., Rosario A. Rajakumar, Robert A. McKnight, Uday P. Devaskar, and Sherin U. Devaskar. Developmental regulation of genes mediating murine brain glucose uptake. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R892–R900, 1999.—We examined the molecular mechanisms that mediate the developmental increase in murine whole brain 2-deoxyglucose uptake. Northern and Western...

Kleine, Teri J., Gerald J. Gleich, and Simon A. Lewis. Eosinophil peroxidase increases membrane permeability in mammalian urinary bladder epithelium. Am. J. Physiol. 276 (Cell Physiol. 45): C638–C647, 1999.—Eosinophil peroxidase (EPO), a cationic protein found in eosinophils, has been reported to be cytotoxic independent of its peroxidase activity. This study investigated with electrophysiologi...

MARK O. BEVENSEE,1 ESTHER BASHI,1 WOLF-RÜDIGER SCHLUE,2 GREGORY BOYARSKY,3 AND WALTER F. BORON1 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520; 2Institut für Neurobiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany; and 3Department of Physiology and Biophysics, University of Texas Medical Branch, Galvesto...

Cui, Jian, Satoshi Iwase, Tadaaki Mano, and Hiroki Kitazawa. Responses of sympathetic outflow to skin during caloric stimulation in humans. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R738–R744, 1999.—We previously showed that caloric vestibular stimulation elicits increases in sympathetic outflow to muscle (MSNA) in humans. The present study was conducted to determine the e...

Hayward, Linda F., and Robert B. Felder. Electrophysiological properties of rat lateral parabrachial neurons in vitro. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R696–R706, 1999.—Anatomical studies have demonstrated that the lateral parabrachial nucleus (LPBN) is composed of at least seven separate subnuclei distinguished by cell morphology, spatial clustering, and afferent...

The application of parallel synthesis to generate combinatorial libraries as an efficient means of creating pharmaceutical “drug-like leads” has gained considerable interest.1,2 By accelerating the synthesis and screening of an ever larger number of synthetic analogues, combinatorial chemistry has greatly impacted the drug discovery process.3 Despite this success, compounds originating from nat...

Teff, Karen L., Abass Alavi, Jergin Chen, Michael Pourdehnad, and Raymond R. Townsend. Muscarinic blockade inhibits gastric emptying of mixed-nutrient meal: effects of weight and gender. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R707–R714, 1999.—We compared the vagal contribution to gastric emptying in lean and obese subjects by monitoring gastric emptying of a meal during...