In analogy with the reaction of phenols very strong super acids, these compounds can be protonated by weaker acid trifluoroacetic (TFA) and trifluoromethanesulphonic (TFS) also giving rise to formation OH and/or ring products, which identified unambiguously means 1HNMR spectroscopy. The same reactions are possible deuterated acids TFA-d TFS-d. However, from reactions, additional information on ...

VEGFR-2 is a critical target for the treatment of solid tumors. This work represents synthetic approaches to new class fenamate-based derivatives with essential pharmacophoric properties comparable inhibitors. The reaction tolfenamic acid hydrazide substituted phenacyl bromide, and phenylisothiocynate produced novel (TA) (compounds 4 5). molecules were validated using spectroscopic techniques s...

Displacement reaction of 2,3-dichloroquinoxaline with secondary amines in boiling ethanol afforded it`s mono aminoquinoxaline derivatives. Further reaction of the latter compounds with sodium azide in warm dimethylsulfoxide achieved a group of 4-amino tetrazolo[1,5-a]quinoxaline derivatives. 1HNMR spectra of these compounds are discussed.

some n¬-acyl-n'-aryl thiourea derivatives 4(a-f) have been prepared by the reaction of acyl halides ammonium thiocyanate and aryl amines. the structures of synthesized compounds have been characterized by ir, 1hnmr spectral studies. the synthesized compounds 5(a-f) have been screened for antibacterial activity. the effect of the structure of the investigated compounds on the antibacterial ...

A series of new hexahydroquinoline and 1,4-dihydropyrimidine derivatives were synthesized. Condensation of 2-methyl- thiazole-4-carboxaldehyde (1) with 1,3-cyclohexanedione and alkyl 3- aminocrotonate afforded 4-(2-methyl-thiazol-4-yl)-hexahydroquinoline while condensation of aldehyde (1) with benzoyl acetone and thiourea gave 1,4-dihydropyrimidine derivatives. The stereochemistry of 1,4-dihydr...

As chitosan’s solubility represents a drawback for further applications, the functionalization of chitosan became attractive by a variety of chemical methods. The present study deals with the chemical modification of chitosan by using click chemistry technique as versatile tool being easy to perform with high yields and no additional by products. The approach used herein was to attach a respons...

Purpose: To study the enzyme inhibition activity of various sulfonamides derived from dagenan chloride. Methods: The synthesis of N-(naphthalen-1-yl)-4-acetamidobenzenesulfonamide (3) was carried out by gearing up 1-naphthylamine (1) with dagenan chloride (2) in water in the presence of Na2CO3 solution. Further, compound 3 was treated with various alkyl/aralkyl halides (4a-o) to yield 5a-o in a...

Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs like cycloguanil and pyrimethamine which target its inhibition for their pharmacological actions. However, the clinical efficacies of these antimalarial drugs have been compromising due ...