Polycystic Ovary syndrome (PCOS) is the most common endocrine disorder affecting 5 - 10% of all women of reproductive age group. The present research was carried out to study the impact of Plasminogen Activator Inhibitor (PAI-1) 4G/5G polymorphism (rs1799889) in PCOS, and the risk of developing PCOS in South Indian Population. The study was carried out in 60 subjects of South Indian population ...

Snail1 is a transcription factor that induces the epithelial to mesenchymal transition (EMT). During EMT, epithelial cells lose their junctions, reorganize their cytoskeletons, and reprogram gene expression. Although Snail1 is a prominent repressor of E-cadherin transcription, its precise roles in each of the phenomena of EMT are not completely understood, particularly in cytoskeletal changes. ...

Objectives This study aimed to assess PD-1gene polymorphism in salivary gland tumors in patients referred to Khalili Hospital in Shiraz. Methods This case-control study evaluated 48 patients with salivary gland tumors and 100 age- and sex-matched healthy controls. First, 5cc blood samples were obtained from patients and transferred to vials containing anti-coagulated EDTA. DNA was extracted, a...

Background: Increased levels of the amyloid ß protein (Aß), oxidative damage, mitochondrial dysfunction and possibly down-regulation of cholinergic neurons are neuropathological markers of Alzheimer's disease (AD). Melatonin; the neurohormone, may act as a protective agent in neurodegenerative diseases such as Parkinson's, Alzheimer's, aging. However, the protective mechanisms of melatonin agai...

Objective(s) The aim of this study was to investigate the presence of PER-1-type ESBLs in drug resistant Pseudomonas aeruginosa isolates. Materials and Methods During one-year period (2008-2009), following isolation and identification of 56 P. aeruginosa, the E-test method was performed for determination of minimal inhibitory concentration of ceftazidim. The isolates that they had MIC≥16 µg/ml ...

von Willebrand disease (VWD) is one of the most common inherited bleeding disorders, with a prevalence of symptomatic disease of;1 in 10 000. Given the complexity of the disease, the ability to accurately and appropriately diagnose individuals with VWD continues to be an important and much discussed topic of interest. In this review, we highlight the current status of clinical testing and diagn...