Although dementia has been described in ancient texts over many centuries (e.g., "Be kind to your father, even if his mind fail him." - Old Testament: Sirach 3:12), our knowledge of its underlying causes is little more than a century old. Alzheimer published his now famous case study only 110 years ago, and our modern understanding of the disease that bears his name, and its neuropsychological ...

Background: The most important cause of neurodegeneration in Alzheimer's disease (AD) is associated with inflammation and oxidative stress. Probiotics are microorganisms that are believed to be beneficial to human and animals. Probiotics reduce oxidative stress and inflammation in some cases. Therefore, this study determined the effects of probiotics mixture on the biomarkers of oxidative stres...

Existing thermal-aware 3D placement methods assume that the temperature of 3D ICs can be optimized by properly distributing the power dissipations, and ignoring the heat conductivity of though-silicon-vias (TSVs). However, our study indicates that this is not exactly correct. While considering the thermal effect of TSVs during placement appears to be quite complicated, we are able to prove that...

Online Ad Servers attempt to find the best ad to serve for a given triggering user event. The performance of the ad may be measured in several ways. We suggest a formulation in which the ad network is trying to maximize revenue subject to relevance constraints. We describe several simple algorithms for ad selection and review their complexity. We tested these algorithms using the Microsoft ad n...

Estimating the size of OO software is the main issue today in project planning and development. Accurate estimation of size may lead to precise prediction of effort during the process of system development. Predictive Object Point POPs are a metric designed specifically for estimating the size of object oriented software. But there is no direct relation between POP and Software size. In this pa...

This paper describes a new planner, HiPOP (Hierarchical Partial-Order Planner), which is domain-configurable and uses POP techniques to create hierarchical time-flexible plans. HiPOP takes as inputs a description of a domain, a problem, and some optional userdefined search-control knowledge. This additional knowledge takes the form of a set of abstract actions with optional methods to achieve t...

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This paper addresses the question of how to increase local coherence in summaries of multi-party conversations. Due to the interactive nature of dialogues, local regions of coherence often stretch across diierent speakers, as for instance in question-answer pairs. We present an approach to automatically detect those regions of local coherence and evaluate the resulting summaries' uency and info...

Algorithmic prediction of RNA secondary structure has been an area of active inquiry since the 1970s. Despite many innovations since then, our best techniques are not yet perfect. The workhorses of the RNA secondary structure prediction engine are recursions first described by Zuker and Stiegler in 1981. These have well understood caveats; a notable flaw is the ad-hoc treatment of multi-loops, ...