نتایج جستجو برای: 1918
تعداد نتایج: 7085 فیلتر نتایج به سال:
Pandemic influenza viruses cause significant mortality in humans. In the 20th century, 3 influenza viruses caused major pandemics: the 1918 H1N1 virus, the 1957 H2N2 virus, and the 1968 H3N2 virus. These pandemics were initiated by the introduction and successful adaptation of a novel hemagglutinin subtype to humans from an animal source, resulting in antigenic shift. Despite global concern reg...
We have prepared a virus-like particle (VLP) vaccine bearing the surface glycoproteins HA and NA of the 1918 influenza A virus by infecting Sf9 cells with a quadruple recombinant baculovirus that expresses the four influenza proteins (HA, NA, M1, and M2) required for the assembly and budding of the VLPs. The presence of HA and M1 in the purified VLPs was confirmed by Western blot, and that of N...
Background. Surveillance for respiratory diseases in domestic National Army and National Guard training camps began after the United States' entry into World War I, 17 months before the "Spanish influenza" pandemic appeared. Methods. Morbidity, mortality, and case-fatality data from 605 625 admissions and 18 258 deaths recorded for 7 diagnostic categories of respiratory diseases, including in...
The cannabinoid analog abnormal cannabidiol [abn-cbd; (-)-4-(3-3,4-trans-p-menthadien-[1,8]-yl)-olivetol] does not bind to CB(1) or CB(2) receptors, yet it acts as a full agonist in relaxing rat isolated mesenteric artery segments. Vasorelaxation by abn-cbd is endothelium-dependent, pertussis toxin-sensitive, and is inhibited by the BK(Ca) channel inhibitor charybdotoxin, but not by the nitric-...
Edward B. Lewis [4] studied embryonic development in Drosophila [5], including the discovery of the cis-trans test [6] for recessive genes [7], and the identification of the bithorax complex [8] and its role in development in Drosophila [5]. He shared the 1995 Nobel Prize in Physiology or Medicine [9] with Christiane Nüsslein-Volhard [10] and Eric F. Wieschaus for work on genetic control of ear...
after the bolshevik revolution in 1917, he three transcaucasian republics (azerbaijan, armenia, georgia) were emerged.but because of the great powers' rivalry in transcaucasia, withholding of recognition of the republics by the allies in paris peace conference (1919), and the continuous conflicts between the republics themselves, the soviet :union: easily defeated the republics and annexed...
The mechanisms responsible for the virulence of the highly pathogenic avian influenza (HPAI) and of the 1918 pandemic influenza virus in humans remain poorly understood. To identify crucial components of the early host response during these infections by using both conventional and functional genomics tools, we studied 34 cynomolgus macaques (Macaca fascicularis) to compare a 2004 human H5N1 Vi...
To understand more fully the molecular events associated with highly virulent or attenuated influenza virus infections, we have studied the effects of expression of the 1918 hemagglutinin (HA) and neuraminidase (NA) genes during viral infection in mice under biosafety level 3 (agricultural) conditions. Using histopathology and cDNA microarrays, we examined the consequences of expression of the ...
R310 Current Biology 25, R301–R327, April 20, 2015 ©2015 Elsevier Ltd All rights reserved wrote. “Furthermore, alumni from 15 different colleges, including green energy entrepreneur Jeremy Leggett and journalist George Monbiot, have promised to hand back their Oxford University degrees if the University does not commit to divestment from fossil fuels.” The UK newspaper The Guardian has recently...
Solomon A. Berson helped develop the radioimmunoassay (RIA) technique in the US during the twentieth century. Berson made many scientific contributions while working with research partner Rosalyn Yalow at the Bronx Veterans Administration (VA) hospital, in New York City, New York. In the more than twenty years that Berson and Yalow collaborated, they refined the procedures for tracing diagnosti...
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