Bisdioxopiperazine drugs such as ICRF-187 are catalytic inhibitors of DNA topoisomerase II, with at least two effects on the enzyme: namely, locking it in a closed-clamp form and inhibiting its ATPase activity. This is in contrast to topoisomerase II poisons as etoposide and amsacrine (m-AMSA), which act by stabilizing enzyme-DNA-drug complexes at a stage in which the DNA gate strand is cleaved...

La présente contribution, croisant des perspectives de la (socio)linguistique et éthiques du care, explore un usage métaphorique verbe « lire » : elle repose sur le postulat que « nos corps sont à lire ». Elle soumet discussion l’hypothèse qu’une lecture « qui prend soin » (caring) peut permett...

Michel Tournier was a philosopher before being novelist. And even when he decided to become novelist, introduced himself as « smuggler of philosophy ». But it is impossible take full measure this statement without considering the one and only philosophical text ever published, in 1946: « L’Impersonnalisme ». This article, which considered be his &#1...

protection from various intellectual deviations is one of the most important aspect that those responsible for security and stability society should address. One these "extremism extremism", which tends to destroy souls. correct perceptions ideas.Therefore European councils intended about manifestations deviation contemporary youth sound thought moves souls towards civilization progress, extrem...

Abstract Background In dementia research, supporting personhood is seen as a corner stone of person-centred care. However, little understood about how conceptualised in the context home and communities that people living with reside within, place may constitute key dimension of, or determining factor someone’s sense self. This study seeks to explore these relationships by examining intersection...