نتایج جستجو برای: 177lu psma

تعداد نتایج: 2383  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Jürgen Grünberg Ilse Novak-Hofer Michael Honer Kurt Zimmermann Karin Knogler Peter Bläuenstein Simon Ametamey Helmut R Maecke P August Schubiger

PURPOSE The L1 cell adhesion protein is overexpressed in tumors, such as neuroblastomas, renal cell carcinomas, ovarian carcinomas, and endometrial carcinomas, and represents a target for tumor diagnosis and therapy with anti-L1-CAM antibody chCE7. Divalent fragments of this internalizing antibody labeled with 67/64Cu and 177Lu were evaluated to establish a chCE7 antibody fragment for radioimmu...

2017
M. Meckel R. Bergmann M. Miederer F. Roesch

Background Bisphosphonates have a high adsorption on calcified tissues and are commonly used in the treatment of bone disorder diseases. Conjugates of bisphosphonates with macrocyclic chelators open new possibilities in bone targeted radionuclide imaging and therapy. Subsequent to positron emission tomography (PET) examinations utilizing 68Ga-labelled analogues, endoradiotheraphy with 177Lu-lab...

Journal: :Nuclear medicine review. Central & Eastern Europe 2013
Jolanta Kunikowska Adam Bajera Magdalena Sawicka Piotr Czwarnowski Bożena Pawłowicz Dariusz Aksamit Dariusz Pawlak Leszek Królicki

BACKGROUND Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms derived from endocrine stem cells.These tumors are characterized by overexpression of somatostatin receptors (SSTR), which is utilized for imaging using SSTR analogs. Peptide receptor radionuclide therapy (PRRT) somatostatin analogs labeled with 90Y and 177Lu in neuroendocrine tumors (NETs) results in symptomatic imp...

2017
Aimen Zlitni Melissa Yin Nancy Janzen Samit Chatterjee Ala Lisok Kathleen L Gabrielson Sridhar Nimmagadda Martin G Pomper F Stuart Foster John F Valliant

Prostate specific membrane antigen (PSMA) targeted microbubbles (MBs) were developed using bioorthogonal chemistry. Streptavidin-labeled MBs were treated with a biotinylated tetrazine (MBTz) and targeted to PSMA expressing cells using trans-cyclooctene (TCO)-functionalized anti-PSMA antibodies (TCO-anti-PSMA). The extent of MB binding to PSMA positive cells for two different targeting strategie...

2017
In Ho Song Youn Noh Junhye Kwon Jae Ho Jung Byung Chul Lee Kwang Il Kim Yong Jin Lee Joo Hyun Kang Chae Seo Rhee Chul Hee Lee Tae Sup Lee Ik Joon Choi

The epidermal growth factor receptor (EGFR) is one of the most comprehensively studied molecular targets in head and neck squamous cell carcinoma (HNSCC). However, inherent and acquired resistance are serious problems and are responsible for limited clinical efficacy and tumor recurrence. In this study, we evaluated the feasibility of immuno-positron emission tomography (PET) imaging and radioi...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017
Anna-Karin Elf Peter Bernhardt Tobias Hofving Yvonne Arvidsson Eva Forssell-Aronsson Bo Wängberg Ola Nilsson Viktor Johanson

Neuroendocrine tumors (NETs) can be treated by peptide receptor radionuclide therapy using radiolabeled somatostatin analogs. However, the efficacy of such treatment is low and needs to be optimized. Our study evaluated the potential radiosensitizing effects of inhibition of nicotineamide phosphoribosyltransferase on 177Lu-DOTATATE treatment in a NET model. METHODS Nude mice xenografted with ...

2015
Thomas P. Shakespeare

BACKGROUND Positron emission tomography (PET) imaging is routinely used in many cancer types, although is not yet a standard modality for prostate carcinoma. Prostate-specific membrane antigen (PSMA) PET is a promising new modality for staging prostate cancer, with recent studies showing potential advantages over traditional computed tomography (CT), magnetic resonance imaging (MRI) and nuclear...

2016
Nafise Salek Mojtaba Shamsaei Mohammad Ghannadi Maragheh Simindokht Shirvani Arani Ali Bahrami Samani

Skeletal uptake of radiolabeled-1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetramethylene phosphoric acid (e.g., 177Lu-DOTMP) complex, is used for bone pain palliation. The moderate energy of β-emitting 177Lu (T½ = 6.7 d, Eβmax = 497keV) has been considered as a potential radionuclide for development of the bone-seeking radiopharmaceutical. Since the specific activity of the radiolabeled car...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید