OBJECTIVE/HYPOTHESIS Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by significant goblet hyperplasia and mucus hypersecretion. However, the molecular mechanism underlying mucin overexpression in CRSwNP has not been well characterized. This study sought to assess the expression of SAM-pointed domain-containing Ets-like factor (SPDEF) and its regulation of mucin production in...

The aims of this study were to evaluate the effectiveness of a lower lingual holding arch (LLHA) in maintaining arch length, and to compare the effectiveness of two LLHAs made of two different gauges (0.9 and 1.25 mm) of stainless steel (SS) wire. The sample comprised 44 subjects (24 males and 20 females) who for various reasons attended orthodontic clinics at Jordan University of Science and T...

BACKGROUND Creatine kinase (CK) is a pivotal regulatory enzyme in energy metabolism linked to both blood pressure and cardio-metabolic components. However, data is lacking in a large population of asymptomatic Asians. METHODS AND RESULTS Cardio-metabolic assessment including anthropometric measures and non-alcoholic fatty liver disease (NAFLD) were evaluated by abdominal echo in 4,562 consecu...

Childhood asthma is frequently perceived as a disease with uniform clinical pathways. This perception might be an oversimplification. The aim of the present study was to investigate the incidence and natural course of wheeze over the first 13 yrs of life and analyse the risk factors predicting wheeze at 11-13 yrs of age. The Multicentre Allergy Study, a German birth cohort, recruited 1,314 chil...

OBJECTIVE To determine the prevalence of lactose malabsorption and its association with skin color and age in children and teenagers attending public schools in Porto Alegre, Brazil. METHODS A cross-sectional study was performed with 225 subjects between 8 and 18 years attending two public schools in Porto Alegre, Brazil. Patients were randomly selected. Subjects were classified according to ...

The objective of this study was to investigate the effect of sequence of resistance and aerobic training on energy consumption on sedentary overweight females. Participants were 15 sedentary overweight females (age = 28.6 ±12 yrs; BMI = 28.1±7.8) Subjects did a counterbalanced intervention: resistance training (circuit training) first (intervention RT) or aerobic exercise first (intervention AT...

The purpose of this study was to analyse the information provided by different techniques used in the assessment of patients with idiopathic pulmonary fibrosis (IPF) and their role in the prediction of lung function decline with the decline. Twenty seven subjects with IPF (55 +/- 14 (mean +/- SD) yrs) were studied at the initial staging. Nineteen of them (70%) were included in a follow-up over ...

Pulses are low in energy density, supporting their inclusion in the diet for the management of risk factors of the metabolic syndrome (MetSyn). The aim of the present study was to describe the effects of frequent consumption (five cups/week over 8 weeks) of pulses (yellow peas, chickpeas, navy beans and lentils), compared with counselling to reduce energy intake by 2093 kJ/d (500 kcal/d), on ri...

BACKGROUND Prior longitudinal studies have shown high cumulative dating violence exposure rates among U.S adolescents, with 36 percent of males and 44 percent to 88 percent of females experiencing victimization across adolescence/young adulthood. Despite promising information characterizing adolescents' dating violence experiences longitudinally, prior studies tended to concentrate on physical ...

To study the physiopathology and significance of asymptomatic airway hyperresponsiveness (AHR), the clinical and bronchial immunohistological parameters were evaluated in subjects with asymptomatic and symptomatic AHR. Asymptomatic subjects with AHR (eight females/two males, no respiratory symptoms, provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one ...