نتایج جستجو برای: 15 benzodiazepine

تعداد نتایج: 501261  

Journal: :Journal of neurology, neurosurgery, and psychiatry 1996
F Kapczinski H V Curran R Przemioslo R Williams E Fluck C Fernandes S E File

OBJECTIVES To determine whether differences in cognitive function between alcoholic and non-alcoholic cirrhotic patients relate to differences in endogenous ligands for the benzodiazepine receptor and/or benzodiazepine binding. METHODS Seventeen grade-I hepatic encephalopathic patients (nine alcoholic, eight non-alcoholic) were compared with 10 matched controls on plasma concentrations of end...

Journal: :Bulletin of the Royal College of Psychiatrists 1988

2017
Tao Zhang Xiaowen Yang Jianrui Zhou Pei Liu Hui Wang Anrong Li Yi Zhou

Conflicting results identifying the relationship between benzodiazepine drug use and cancer risk. Therefore, we conducted a dose-response meta-analysis of prospective cohort studies to clarify and quantitative assessed the relationship between benzodiazepine drug use and cancer risk. Up to July 2017, 22 original publications were included in current meta-analysis. Our results showed statistical...

Journal: :The British journal of general practice : the journal of the Royal College of General Practitioners 2002
S M Zandstra J W Furer E H van de Lisdonk J H J Bor F G Zitman C van Weel

BACKGROUND Despite generally accepted advice to keep treatment short, benzodiazepines are often prescibed for more than six months. Prevention of long-term benzodiazepine use could be facilitated by the utilisation of risk indicators for long-term use. However, the characteristics of long-term benzodiazepine users described in the literature are based on studies in which long-term users were co...

Journal: :iranian journal of pharmaceutical research 0
fatemeh ahmadi department of radiopharmacy, school of pharmacy, tehran university of medical sciences sara dabirian department of pharmaceutical chemistry, school of pharmacy, shahid behesti university of medical sciences mehrdad faizi department of pharmacology and toxicology, school of pharmacy, shahid beheshti university of medical sciences sayyed abbas tabatabai department of pharmaceutical chemistry, school of pharmacy, shahid behesti university of medical sciences davood beiki research center for nuclear medicine, tehran university of medical sciences soraya shahhosseini department of pharmaceutical chemistry, school of pharmacy, shahid beheshti university of medical sciences

to obtain drugs which are more selective at benzodiazepine (bzd) receptors, design and synthesis of functionally selective ligands for bzd receptors is the current strategy of our pharmaceutical chemistry department. the affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

Journal: :Neuroscience letters 1984
A B Young H S Pan B J Ciliax J B Penney

GABA and its associated benzodiazepine interactions play an important role in basal ganglia function. Distinctive GABA, benzodiazepine and opiate receptor changes occur in response to striatal lesions and in the human neurodegenerative disorder, Huntington's disease (HD). In animal experiments, the in vivo administration of [3H]flunitrazepam labels benzodiazepine receptors and can demonstrate t...

Journal: :Journal of Korean Medical Science 2003
Joong-Seok Kim Seok-Bum Ko Yeong-Bin Choi Kwang-Soo Lee

Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is un...

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