BACKGROUND Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung carcinoma (NSCLC) accounts for most of the lung cancer cases and the prognosis of this disease remains poor despite decades of intensive investigation. Thus new insights into underlying mechanisms by which NSCLC develops are avidly needed as the basis for development of new lines of therapeutic st...

We employ theoretical and computational techniques to construct new weighing matrices constructed from two circulants. In particular, we construct W (148, 144), W (152, 144), W (156, 144) which are listed as open in the second edition of the Handbook of Combinatorial Designs. We also fill a missing entry in Strassler’s table with answer ”YES”, by constructing a circulant weighing matrix of orde...

Section 144 of the Labour Relations Act 66 1995 provides for rescission and variation arbitration awards. Two schools thought have emerged from Appeal Court judgments dealing with rescission. This is to a large extent attributable similarity wording section Rule 42(1) Uniform Rules Court. The first view that wide meaning should be given 144. approach requires reasonable explanation bona fide de...

P roper cholesterol homeostasis requires a complex network of sterol-sensing proteins, membrane dynamics, and extensive regulation of transcription, translation, posttranslation modifications, and protein turnover. Together, multilayered regulatory modules control 3 key processes to balance cellular cholesterol levels: de novo cholesterol biosynthesis, cholesterol uptake through lipoprotein rec...

RATIONALE Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and mortality in Western societies. Liver X nuclear receptors (LXRs) regulate the expression of the adenosine triphosphate-binding cassette (ABC) transporters, including adenosine triphosphate-binding cassette transporter A1 (A...

BACKGROUND Thyroid cancer is the most common malignancy of endocrine system, and papillary thyroid cancer (PTC) is the most common subtype. E2F8, a novel identified E2F family member, was reported to associate with progression of several human cancers, however, its clinical significance and biological role in PTC remain unknown. METHODS E2F8 or miR-144 expression profiles in PTC tissues were ...

In a series of related experiments to evaluate the relative toxicity of inhaled radionuclides, beagles were exposed to aerosols containing relatively soluble (chloride) or relatively insoluble (fused clay) forms of 144-Ce and 90Sr. With the solubled 144-CeCl3, significant radiation doses were delivered to the lungs, liver, and skeleton whereas, after 90-SrCl2 exposure, the radiation dose was de...

Distraction osteogenesis (DO), one of effective therapies for bone regeneration, has been received more attention in recent years. However, the underlying mechanism remains elusive. Recently, microRNAs (miRNAs) have been reported to play important roles in regulating osteogenesis and bone formation. We therefore provided the hypothesis that miRNAs could involve in the DO-mediated bone regenerat...

In our previous studies, the Illumine Soledad massively parallel signature sequencing of miRNomes in non‑tumor and hepatocellular carcinoma (HCC) tissues revealed that microRNA (miR)-144-3p was significantly downregulated in HCC, but its role in HCC development, especially angiogenesis, remains unclear. In this investigation, we found recovering miR‑144‑3p expression can significantly suppress ...

Regional lymph node metastasis and distant metastasis are critical in the prognosis of laryngeal squamous cell carcinoma (LSCC). This study investigated the roles of miR-144-3p and E26 transformation specific-1 (ETS-1) in the invasion and migration of LSCC cells. The effects of miR-144-3p and ETS-1 on FaDu and Hep2 cell growth, migration and invasion were determined. Suppression of ETS-1 by miR...