5-Arylisoxazolyl-3-carboxaldehydes were condensed with N-aryl acetoaceta¬mide and ammonium acetate in methanol to give N3,N5-diaryl-4-(5-arylisoxazol-3-yl)-1,4-dihydropyridine-3,5-dicarboxamides. All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv). The results for new synthesized compounds showed a moderate activity in comparison to rifampicin.

Each of the four repeats (or motifs) of voltage-gated ion channels is thought to contain six transmembrane segments (S1-S6). Mutational analyses indicate that S4 functions as a voltage sensor and that the S5, S6, and S5-S6 linker contribute to formation of the ion pore. However, little information exists regarding the functional role(s) of the amino-terminal portion (S1-S3-S4 linker) of the rep...

Short-term treatment of the endothelium with dihydropyridine calcium antagonists resulted in an increased release in NO that is not due to a modulation of L-type calcium channels, because macrovascular endothelial cells do not express this channel. We investigated whether long-term (48 hours) treatment of porcine endothelial cell cultures with the dihydropyridine calcium antagonist nifedipine r...

BACKGROUND The effects of the 3 classes of L-type calcium-channel blockers (CCBs) on vascular endothelial function have not been clarified in patients with coronary vasospasm. METHODS AND RESULTS Twenty-five normotensive patients (age 64.0+/-1.4 years) with coronary vasospasm were randomly treated for 3 months with benidipine, diltiazem, and verapamil, which belong to the dihydropyridine, ben...

RATIONALE Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca(2+) channels and their renowned antioxidant properties. METHODS We synthesized six novel dihydropyridine molecules and performed docking studies on the binding site of the L-type Ca(2+) channel. We used biochemical techniques on isolated adult rat cardiomyocytes...

Reaction of methoxyvinylmethylketone with different amines and aldehydes under Lewis-acid catalysed conditions results in a novel, formal, step-wise [1+2+1+2]-cycloaddition to give dihydropyridine products.

1,4 Dihydropyridines are very versatile compounds and have important role as therapeutic agents. The 1, 4 (1,4 DHPs) well known calcium channel blocker their use in treatment of cardiovascular diseases is common. These also to antimicrobial activities. N-heterocyclic represent framework for agricultural pharmaceutical industries. antibacterial antifungal Hence, the substituted 4- Dihydropyridin...