The interaction of the epidermal growth factor (EGF) with its receptor (EGFR) is known to be complex, and the common over-expression of EGF receptor family members in a multitude of tumors makes it important to decipher this interaction and the following signaling pathways. We have investigated the affinity and kinetics of (125)I-EGF binding to EGFR in four human tumor cell lines, each using fo...

This experiment was carried out to evaluate the effect of silver nanoparticles pulsing treatment (0, 25, 75 and 125 mg L−1) on vase life and some postharvest physiological parameters of cut rose flower ʻHigh & Magicʼ in sucrose solution (0, 2 and 3%). This research performed as a factorial experiment based on a completely randomized design with three replications under 23 ± 2 °C, 60 ± 5% RH and...

background: ovarian cancer is the fifth leading cause of death from malignancy in women. cd4 +cd25+foxp3+ regulatory t (treg) cells are a subset of t lymphocytes with great inhibitory impact on immune response. objectives: to investigate the percentage of cd4 +cd25+foxp3+ regulatory t cells in the peripheral blood of the iranian patients with epithelial ovarian cancer compared to healthy women ...

In order to evaluate the effect of plant growth regulators on sex determination and yield, an experiment was conducted by spraying different hormonal combinations on medicinal pumpkin. Experimental treatments were included different concentrations of NAA (25, 75, 100, 125 mg/l), paclobutrazol (50, 100, 200 and 300 mg/l) and combination of growth regulators (NAA 25 mg/l + PBZ 50 mg/l), (NAA 75 m...

Two monoclonal antibodies, OC 125 and OC 133, bind to distinct determinants on the surface of human epithelial ovarian carcinoma cell lines. OC 125 and OC 133 recognize determinants on molecules with molecular weights greater than 200,000 and 80,000, respectively. When binding to four different cell lines was compared, apparent affinity constants for OC 125 ranged from 3.1 X 10(9) to 6.0 X 10(7...

I. I n t r o d u c t i o n . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122 l . l . H i s to r i ca l Perspec t ive . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 1.2. P I I I Div ided . . . . . . . . . . . . . . . . . . . ...

The best available marker for epithelial ovarian cancer is still considered to be CA-125 due to a combination of reliability and general availability. HE4 is more sensitive than specific than CA-125, however the former is not in routine use. NICE still therefore recommends CA-125 rather than HE4. CA-125 is used for the diagnosis of epithelial ovarian cancer. αFP and βHCG are useful for identify...

Negative-pressure wound therapy has recently gained popularity in chronic wound care. This study attempted to explore effects of different negative pressures on epithelial migration in the wound-healing process. The electric cell-substrate impedance sensing (ECIS) technique was used to create a 5 x 10(-4) cm(2) wound in the Madin-Darby canine kidney (MDCK) and human keratinocyte (HaCaT) cells. ...

(E) ω-formylcamphene was synthesized from α-pinene, the main component of turpentine, and then reacted with thiosemicarbazide to obtain 3, which 14 α-bromoacetophenone compounds thiazole hydrazone 5a–5n; yields were all above 80%. The structures target characterized by IR, 1H-NMR, 13C-NMR, HR-MS analyses. Then, 500, 250, 125, 62.5, 31.25 mg/L drug solutions prepared. Free radical scavenging exp...

MicroRNAs (miRNAs) are emerging as a novel class of non-coding RNA molecules that regulate gene expression at a post-transcriptional level. More than 1000 miRNAs have been identified in human cells to date, and they are reported to play important roles in normal cell homeostasis, cell metastasis and disease pathogensis and progression. MiR-125, which is a highly conserved miRNA throughout diver...