The thioredoxin (TRX) system (TRX, TRX reductase, and NADPH) is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/oxidation (redox) status. The oxidation mechanism for disease pathogenesis states that an imbalance in cell redox state alters function of multiple cell pathways. In this study, we review the essential role for TRX to limit oxidative stress directly via anti...

The HL-LHC is being designed to deliver an integrated luminosity of at least 250fb−1/year in each of the two LHC General-Purpose Experiments ATLAS and CMS for proton operation [1], while operating the other two experiments, ALICE and LHCb, at very low and moderate instantaneous luminosity, of about 10 and 1–2×1033 cm−2s−1, respectively [2, 3]. The ambitious performance target for ATLAS and CMS ...

nous literature, and the diverse opinions as to its pathology, comes malaria. To the Army Surgeon, who sees more of malarial fevers than any other section of the medical profession, the subject of the paroxysmal fevers, however approached, must be of surpassing interest and importance. To all who have seen much of malarial fevers, instances of co-existing jaundice and hsematinuria must be famil...

Models of supersymmetric grand unified theories based on SU(5)GUT×U(N)H gauge group (N = 2, 3) have a symmetry that guarantees light two Higgs doublets and absence of dimension-five proton decay operators. We analysed the proton decay induced by gauge-boson exchange in the models. Upper bounds of proton life-time are obtained; τ(p → πe)∼ 6.0×1033 yrs. in the SU(5)GUT×U(2)H model and τ(p → πe)∼ ...

Elisa Rebolini,1,2,4,* Julien Toulouse,1,2,† Andrew M. Teale,3,4,‡ Trygve Helgaker,4,§ and Andreas Savin1,2,∥ 1Sorbonne Universités, UPMC Université Paris 06, UMR 7616, Laboratoire de Chimie Théorique, F-75005 Paris, France 2CNRS, UMR 7616, Laboratoire de Chimie Théorique, F-75005 Paris, France 3School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom 4...

Two classes of neutron stars may exist in the galactic halo: neutron stars originating in the disk with high velocities and neutron stars originating in globular clusters (via Type II supernovae and/or accretion induced collapse).Moreover, the halo dark matter is likely in the form of dark clusters composed of MACHOs and cold molecular clouds. Here we propose a model in which neutron stars cros...

Inhibiting epidermal growth factor receptor (EGFR) signaling has proven to be an effective strategy for treating non-small cell lung cancer (NSCLC) patients and the first generation of agents developed for this purpose, gefitinib and erlotinib, stimulated a unique escalation in both biologic and clinical research within the field. Second-generation EGFR-targeted agents that aim to further impro...